山东医药2012，Vol.52Issue(16)：37-38,2.
吡咯烷二硫代氨基甲酸对大鼠急性肺损伤TNF-α的影响
Influence of pyrrolidine dithiocarbamate on the tumor necrosis factor-α in rats with acute lung injury
摘要
Abstract
Objective To investigate the influence of pyrrolidine dithiocarbamate (PDTC) on the tumor necrosis fac-tor-α in rats with acute lung injury ( ALI) induced by lipopolysaccharide (LPS). Methods A total of 66 male rats were randomly divided into 3 groups. The rats in control group (N group, n = 6) were injected into the peritoneal cavity with normal saline, in lung injury group ( L group, n = 30) with LPS to reproduce ALI model, and in PDTC group ( P + L group, n =30) with LPS and PDTC. The samples of L group and P + L group were taken for TNF-α in lung homogenate and blood plasma all h, 2 h, 4 h, 8 h and 12 h. Result Compared with N group, TNF-α increased significantly in L group ( P < 0.01) and was better in P + L group ( P < 0.05 ). Conclusions LPS caused amount of TNF-α release in lung homogenate and blood. It suggestes that NF-κB involves in control of inflammation and plays an important role in ALI. PDTC can control the expression and release of inflammation, and effectively relieve the ALI induced by LPS.关键词
脂多糖/急性肺损伤/肿瘤坏死因子-α/吡咯烷二硫代氨基甲酸Key words
lipopolysaccharide/ acute lung injury/ tumor necrosis factor-a/ pyrrolidine dithiocarbamate分类
医药卫生引用本文复制引用
王红嫚,薛关生,万义增,王东辉,徐文颖..吡咯烷二硫代氨基甲酸对大鼠急性肺损伤TNF-α的影响[J].山东医药,2012,52(16):37-38,2.基金项目
辽宁省教育厅资助项目(L2010311). （L2010311）
