山东医药2012，Vol.52Issue(19)：13-15,3.
胃癌患者围术期血浆Aβ水平变化及与术后认知功能障碍的关系
Changes of plasma levels of β-amyloid protein and its relationship with postoperative cognitive dysfunction in stomach cancer patients
摘要
Abstract
Objective To observe the peioperative change of plasma beta-amyloid protein(Aβ) in stomach cancer patients, and explore its correlation with postoperative congnitive dysfunction(POCD). Methods Fifty patients scheduled for resection of stomach cancer under sevoflurane anesthesia were enrolled in the study, the patients'cognitive functions were assessed using a neuropsychological tests, on the day before the surgery and then again 1 week after the surgery, the incidence rate of POCD was counted. Venous blood samples were taken for the measurement of plasma Aβ before operation (TO), at 2 h(Tl), 4 h(T2) during operation, 24 h(T3) and 48 h(T4), the 7th day(T5), post operation. Results Forty-six patients completed neuropsychological testing, 9 cases (19.6% ) occurred POCD ( POCD group) and 37 cases not (non POCD group). The plasma Aβ levels in POCD group at Tl ~ T5 were significantly higher then that at TO, especially at T3, T4 (P < 0.05, 0.01); In the iron POCD group, the plasma Aβ levels at Tl - T5 were also higher than that at TO, but no significant differences was found at each time point (P > 0.05 ). Conclusions The perioperative plasma Aβ levels of stomach cancer patients increases, and which is related with the occurrence of POCD.关键词
全身麻醉/β-淀粉样蛋白/术后认知功能障碍Key words
general anesthesia/ β-amyloid protein/ postoperative cognitive dysfunction分类
医药卫生引用本文复制引用
李希明,刘中凯..胃癌患者围术期血浆Aβ水平变化及与术后认知功能障碍的关系[J].山东医药,2012,52(19):13-15,3.基金项目
山东省2011年科学技术发展计划(政策引导类)项目(2011YD18070). （政策引导类）
