超高效液相色谱-四极杆飞行时间质谱快速检测动物饲料中10种违禁精神药物OA北大核心CSCDCSTPCD
Simultaneous determination of 10 unapproved sedative drugs in feeds by ultra-performance liquid chromatographyquadrupole-time-of-flight mass spectrometry
建立了测定动物饲料中三唑仑、艾司唑仑、硝西泮、地西泮、异丙嗪、氯氮平、唑吡坦、甲硫哒嗪、氯丙嗪和咪达唑仑10种违禁精神药物的超高效液相色谱-四极杆飞行时间质谱(UPLC-Q-TOF-MS)方法.样品经混合溶剂甲醇-0.1 mol/L HCI(9:1,v/v)振荡提取,再用MCX固相萃取柱净化处理后,采用UPLC-Q-TOF-MS分析检测.10种化合物在5～100μg/L范围内均呈良好的线性关系,线性相关系数均大于0.99.本方法的硝西泮、唑吡坦和…查看全部>>
A new analytical method using ultra-performance liquid chromatography-quadrupole-tlme-of-flight mass spectrometry ( UPLC-Q-TOF-MS) was developed for screening and confirmation of 10 unapproved sedative drugs in feeds. The samples were extracted using the solution of methanol-0. 1 mol/L HCl (9:1, v/v) , and the extracts were centrifuged and then directly purified through MCX cartridges. The identification and detection were achieved in positive elec-trospray …查看全部>>
许成保;锁然;张峰;储晓刚;丁菲;凌云;杨敏莉;孙利
河北农业大学,河北保定071001中国检验检疫科学研究院,北京100123河北农业大学,河北保定071001中国检验检疫科学研究院,北京100123中国检验检疫科学研究院,北京100123中国检验检疫科学研究院,北京100123浙江中医药大学,浙江 杭州 310053中国检验检疫科学研究院,北京100123
化学化工
超高效液相色谱-四极杆飞行时间质谱违禁精神药物饲料
ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS) unapproved sedative drugs feeds
《色谱》 2012 (5)
457-462,6
国家科技支撑计划项目(批准号:2009 BADB9B02)、质量检验公益性行业科研项目(批准号:200910145)、国家质量监督检验检疫总局科技计划项目(批准号:2008IK167)和北京市科技计划项目(批准号:D08050200310803).
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