生物信息学2012，Vol.10Issue(2)：75-78,4.DOI:10.3969/j.issn.1672-5565.2012.02.02
基于约束的建模方法在代谢网络中的应用研究
Researching on the application of constrain - based modeling methods in metabolic networks
摘要
Abstract
Metabolic network plays an important role in cellular function and process. As the rapid development of cellular networks reconstruction, there are more and more available genome - scale metabolic networks, and thus computational modeling methods are increasingly important in investigation of the structure and function of these networks. Constrain -based modeling methods don't like the graph theory methods which study the pure topologi-cal structure of metabolic model, neither like dynamics methods which need detailed kinetic parameters, thus with more advantages in metabolic network modeling. The article studied Staphylococcus aureus metabolic network which contains 619 genes, 655 metabolites and 743 metabolic reactions with constrain - based modeling methods, we mainly studied the topological features, optimal growth rates, dynamic growth and gene deletion of the model. The study provided a primary framework of Staphylococcus aureus with constrain - based modeling.关键词
动力学/代谢网络/建模/图论/系统生物学Key words
dynamics/ metabolic network/ modeling/graph theory/ systems biology.分类
信息技术与安全科学引用本文复制引用
丁德武..基于约束的建模方法在代谢网络中的应用研究[J].生物信息学,2012,10(2):75-78,4.基金项目
安徽省教育厅自然科学基金资助项目(编号:KJ2010B133). （编号:KJ2010B133）
