生物信息学2012，Vol.10Issue(2)：125-129,5.DOI:10.3969/j.issn.1672-5565.2012.02.13
基于特征片段信息的PH domain-like barrel蛋白质折叠类型分类方法
A method of PH domain-like barrel protein fold classification based on characteristic fragments
摘要
Abstract
Folding is an important issue for protein classification. Based on the classification of SCOP1.75, 61 proteins ( <25% sequence identity) of PH domain-like barrel are selected, we get the template of folding types and the corresponding characteristic parameters by analysing the structure. Using the contrast information between the template and the spatial structure of the test proteins, this paper presents a new scoring function Fscore. Establishes a protein folding type classification method based on Fscore and applies it to this folding type classification. In As-trall.75 database, we select 16712 proteins ( <95% sequence identity) as the testing sample, the sensitivity is 99.97%. The result indicates that characteristic parameters describe the nature of the folding type, the scoring function Fscore and the classification method based on Fscore can be used for automatic classification of PH domain - like barrel protein folding type.关键词
折叠类型/标准模板/打分函数/折叠类型分类Key words
Folding type/ Standard template/ Scoring function/ Folding type classification分类
化学化工引用本文复制引用
孔令强,李晓琴..基于特征片段信息的PH domain-like barrel蛋白质折叠类型分类方法[J].生物信息学,2012,10(2):125-129,5.基金项目
北京市自然科学基金(4112010,KM201110005027)资助项目. （4112010,KM201110005027）
