重组慢病毒介导的NMD途径因子UPF1和SMG1可诱导干扰细胞株的构建OA北大核心CSCDCSTPCD

Nonsense-mediated decay (NMD) is well known by the lucid definition of being a RNA surveillance mechanism that ensures the speedy degradation of mRNAs containing premature translation termination codons. The definition of aberrant transcription and start of NMD are determined by the protein complex binding on EJC,where UPF1 and SMG1 play key role for NMD path. UPF1 is a RNA helicase and a RNA-dependent ATPase. SMG1 is responsible for UPF1 phosphorylation as …查看全部>>