山西医科大学学报2012，Vol.43Issue(4)：293-296,4.DOI:10.3969/J.ISSN.1007-6611.2012.04.016
18F-FDG PET/CT在诊断多发性骨髓瘤中的临床应用
Clinical application of 18F-FDG PET/CT in diagnosis of multiple myeloma
郭烽 1赵文锐 1川玲 1梁英魁 1王升 1雷霄1
作者信息
- 1. 中国人民解放军海军总医院核医学科,北京100048
- 折叠
摘要
Abstract
Objective To investigate the features of 18F-FDG PET/CT for multiple myeloma (MM) and to explore the value of 18F-FDG PET/CT in the diagnosis of MM. Methods 18F-FDG PET/CT imaging findings were retrospectively analyzed in 19 patients with MM proved by bone marrow aspiration biopsy. SUVmeam of those lesions were measured. Results All patients suffered from multiple lesions in bone. A total of 221 lesions(about 85.3% of all lesions) were found by CT, which showed as punched out or bubbly lytic destructions of bone. All lesions were mostly found in none marrow of axial skeleton, and rarely formed soft tissue masses and extr-amedullary organ involvement. A total of 198 lesions(about 76.4% ) in bone got focal 1SF-FDG uptake increasing in PET and SUVmeam was 3.1 ±1.4(1.3 -7.4). PET of the lesions with hvpermetabolism were generally matched with CT results, but not matched completely in some lesions. Characteristics of PET/CT images were categorized into three types: ①Multiple bone destructions were shown by CT in partial patients, which mismatched with the hvpermetabolism lesions by PET. ②Some lesions were found with hyperme-tabolism by PET, but no bone destructions in CT. ③The bone destructions combined with soft tissue mass with hypermetabolism in PET were similar to CT results. Two patients with negative results by routine bone marrow aspiration were proved as MM by bone marrow biopsy guided by PET/CT. Conclusion. 18F-FDG PET/CT imaging has an important value in diagnosing MM. Bone marrow aspiration biopsy guided by "F-FDG PET/CT can improve the diagnostic sensitivity, especially in those false-negative patients.关键词
多发性骨髓瘤/PET/CT/18氟-脱氧葡萄糖/正电子发射断层显像术Key words
multiple myeloma/PET/CT/18F fluorodeoxyglucose/positron-emission tomography分类
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郭烽,赵文锐,川玲,梁英魁,王升,雷霄..18F-FDG PET/CT在诊断多发性骨髓瘤中的临床应用[J].山西医科大学学报,2012,43(4):293-296,4.
