摘要
Abstract
Objective To investigate the clinical characteristics of polycystic ovary syndrome(PCOS) patients with insulin resistance and non-insulin resistance for providing a basis for the reasonable treatment of PCOS. Methods According to the homeostasis model insulin resistance index (HOMA-IR) ,92 patients with PCOS were divided into two groups:IR group(n =60) and NIR group(n=32). The age, body mass index (BMI), waist circumference, hip circumference, waist to hip ratio (WHR), Ferriman-Gallwey ( FG) score and acne grade were determined and recorded,and the levels of endocrine hormones were detected in serum. The oral glucose tolerance test( OGTT) and insulin release test( IRT) in both groups were observed. The magnetic particle-based enzyme immunoassay was used to detect the levels of luteal hormone (LH) in the serum,follicle stimulating hormone (FSH) .estrogen (E2),progesterone (P) .prolactin (PRL) and testosterone (T). The glucose oxidase was used to measure the contents of fasting blood glucose and postprandial glucose at 60 min,120 min and 180 min. Radioimmunoassay was employed to measure the levels of fasting insulin and postprandial glucose at 60 inin, 120 min and 180 min. The data were statistically analyzed using SPSS 17.0 software. Results The values of obesity,waist circumference ,hip circumference,waist to hip ratio and BMI in IR group were higher than that in NIR group (P <0. 05), the levels of blood glucose in OGTT at each time point, area under the curve (GAUC) and levels of insulin at each time point, insulin area under the curve (IAUC), HOMA-IR were significantly higher in IR group than those in NIR group (P <0. 01), while the insulin sensitivity index (ISI) in IR group was significantly lower than that in NIR group (P <0. 01). The value of LH / FSH was lower in IR group than that in NIR group, while the E2 was higher in IR group than that in NIR group. Conclusion IR can promote the obesity in PCOS patients, especially the abdominal obesity,and is closely associated with disorder of glycometabolism. Early intervention has great importance to prevent the long term complications in patients with PCOS.关键词
多囊卵巢综合征/体重指数/胰岛素抵抗Key words
polycystic ovary syndrome/body mass index/insulin resistance分类
医药卫生
