山西医科大学学报2012，Vol.43Issue(4)：312-315,4.DOI:10.3969/J.ISSN.1007-6611.2012.04.021
帕瑞昔布钠在膝关节镜手术中的应用
Application of parecoxib sodium during arthroscopic knee surgery
郑寅曦 1徐宏伟 1刘进1
作者信息
- 1. 四川大学华西医院麻醉科,成都610041
- 折叠
摘要
Abstract
Objective To explore the feasibility of parecoxib sodium in arthroscopic knee surgery. Methods Sixty patients undergoing arthroscopic meniscus repair or arthroscopic debridement were randomly assigned into parecoxib sodium group and control group. After femoral nerve block, patients in parecoxib sodium group were intravenously administered 40 mg parecoxib sodium ( diluted by 5 ml normal saline) 15 nun before operation,while patients in control group were injected with S ml normal saline. The hemodynamic variables, dosage of propofol,recovery time and perioperative side effects were observed. Results The demographic characteristics were similar in 2 groups. Dosage of propofol was less in parecoxib sodium group than in control group[(163. 6 ±65. 2) mg vs (204. 7 ± 74.1) mg,P <0. 05 ]. The incidence of respiratory inhibition (16. 7% vs 66. 7% ,P < 0. 001) and body movement during operation ( 16.7% vs 70.0% ,P <0.001) were significantly lower in parecoxib sodium group than in control group. Hemodynamics of patients during operation kept steady, and there was no significant difference between two groups in the term of hemodynamic parameters at each time point,awakeness time and postoperative side effects. Conclusion Parecoxib sodium given before arthroscopic surgery can reduce the dosage of propofol,and therefore femoral nerve block with propofol-TCI for sedation might be a more safe and efficient anesthesia modality.关键词
帕瑞昔布钠/股神经阻滞/膝关节镜手术Key words
parecoxib sodium/femoral nerve block/arthroscopic knee surgery分类
医药卫生引用本文复制引用
郑寅曦,徐宏伟,刘进..帕瑞昔布钠在膝关节镜手术中的应用[J].山西医科大学学报,2012,43(4):312-315,4.
