陕西医学杂志2012，Vol.41Issue(7)：816-818,3.
阿托伐他汀对急性心肌梗死患者择期PCI术后心肌灌注及心功能的影响
Effects of atorvastatin on improving myocardium reperfusion and heart function in patients with acute myocardial infarction after delayed percutaneous coronary intervention
李勇 1郑群 1杨红梅 1张颖轩 1张慧晶 1张俊岭 1李拥军2
作者信息
- 1. 河北省衡水市哈励逊国际和平医院,衡水,053000
- 2. 河北医科大学第二医院心内科
- 折叠
摘要
Abstract
Objective: To explore the effects of atorvastatin on myocardium reperfusion and heart function in patients with acute myocardial infarction after delayed percutaneous coronary intervention (PCI). Methods: 120 patients with acute myocardial infarction (AMI) were randomly divided into 2 groups ,atorvastatin-treated group(60 cases) and routine -treated group(60 cases). The patients in the two groups were all received the coronary secondary prevention,the atorvastatin-treated group added atorvastatin (20mg, one time per day) on 7 days beforePCI. The corrected TIMI frame count(CTFC) , coronary blood welocity were observed on 15minutes after PCI. Analysis of myocardial perfusion tomography in two patients was performed on 2 weeks after PCI. The indices of cardiac function in two groups including LVEF,LVEDD and LVESD were measured by QG SPECT soft. Results: The corrected TIMI frame count(CTFC)in atorvastatin-treated group were significantly lower than those in control group(26. 28 ± 5. 71)vs(35. 12 ±6. 18) ,but coronary blood welocity in atorvastatin-treated group were significantly higher than those in control group(151. 23±36. 7)mm/s vs(130. 82±40. 2)mm/s. In atorvastatin-treated group, points of myocardial perfusion imaging (2. 0±0. 5)were significantly lower than those in routine -treated group(3. 5±0. 6). In atorvastatin-treated group,left ventricular end diastolic volume(56. 6±1. 4)and left ventricular end systolic volume(44. 7±1. 4) were all decreased while left ventricular ejection fraction(0. 58±0. 05) improved markedly than those in controls (0. 41±0. 08). Conclusion; Administration of atorvastatin before delayed PCI may significantly improve myocardial microvascular perfusion and cardiac function.关键词
心肌梗塞/药物疗法/阿托代他汀/放射摄影术,介入性/心肌灌注显像Key words
Myocardial infarction/drug therapy/〢torvastatin/Radiography, interventional/Myocardial perfusion imaging分类
医药卫生引用本文复制引用
李勇,郑群,杨红梅,张颖轩,张慧晶,张俊岭,李拥军..阿托伐他汀对急性心肌梗死患者择期PCI术后心肌灌注及心功能的影响[J].陕西医学杂志,2012,41(7):816-818,3.
