实用妇产科杂志2012，Vol.28Issue(5)：390-393,4.
已婚女性宫颈上皮细胞中人乳头瘤病毒基因分型2000例分析
Analysis of 2000 Cases of Human Papillomavirus Genotyping in Cervical Epithelium
摘要
Abstract
Objective:To explore the distribution of 23 genotypes of human papillomavirus (HPV) in 2000 married women of Nanjing City. Methods :23 types of HPV genetype in cervical epithelium from 2000 cases of married women in Yangzi Petrochemical Group Company of Nanjing Ctiy were tested by PCR and gene-chips technique and the results were analyzed. Results:205 positive results were found in 2000 cervical cell samples, the total HPV infection rate was 10. 25% (205/2000) .the HPV infection rate of a single type was 8. 80% (176/2000). The predominant type from single infection with HPV was type 43 ( 1. 65%, 33/2000), secondly type 58 ( 1.10%, 22/2000). The infection rate of mixed HPV type was 1.45% (29/ 2000) ,the predominant types from mixed infection were HPV 16 +X or HPV 16 +X + X (34.48% ,10/29), secondly HPV43 + X or HPV 43 +X + X(31. 03%,9/29). Conclusions: HPV 43.58,HPV 16 +X or HPV 16 + X + X, HPV 43 + X or HPV 43 + X + X are the main genotypes of 2000 married women in Nanjing district. Gene chip technology had high sensitivity and specificity in detecting multiple HPV genotypes in cervical epithelium, which is useful in the prevention and etiology study of cervical cancer.关键词
已婚女性/宫颈上皮细胞/人乳头瘤病毒/基因分型/基因芯片技术Key words
Married women/ Cervical cell/ Human papillomavirus/ Genotyping/ Gene chip technology分类
医药卫生引用本文复制引用
严粉琴,耿建祥,肖微,朴正爱,唐进,龙秀荣,唐永发,张劲松,李苗苗..已婚女性宫颈上皮细胞中人乳头瘤病毒基因分型2000例分析[J].实用妇产科杂志,2012,28(5):390-393,4.基金项目
江苏省南京市卫生局中医专项支助项目(编号:2009-92) （编号:2009-92）
