实用肝脏病杂志2012，Vol.15Issue(4)：291-294,4.DOI:10.3969/j.issn.1672-5069.2012.04.008
血清细胞角蛋白18诊断非酒精性脂肪性肝病的价值探讨
Serum cytokeratin 18 levels in the diagnosis of patients with nonalcoholic fatty liver diseases
摘要
Abstract
Objective To investigate serum cytokeratin (CK18) levels in the diagnosis of patients with nonalcoholic fatty liver diseases (NAFLD). Methods Ninety-three patients with NAFLD and forty-four healthy persons matched with age and gender were included in this study. Serum ALT, AST, GGT, CK18,FBG,FINS,TC, TG, HDL, LDL, DBP, SBP, height, weight, WC, HC, and waist hip ratio, body mass index and homoeostasis model assessment of insulin resistance were calculated. There were thirty patients with NAFLD undergoing liver bioposy. Results There was an significantly high serum CK18 levels in patients with NAFLD as compared with control subjects (P<0.001) ; serum CK18 level in patients with elevated ALT group (16.38±8.1ng/ml) was higher than in normal ALT group (5.655±4.72ng/ml,P<0.001) ; serum CK18 level (20.93±8.07ng/ml) in NASH group was higher than in NAFL group (7.61 ±5.51ng/ml,P<0.001) ;Serum CK18 level was positively correlated to the degree of steatosis (r=0.527,P=0.003) ,lobular inflammation (r=0.662,P<0.001) ,and fibrosis (r=0.715,P<0.001). Conclusion Serum CK18 level reflects the degree of lobular inflammation and fibrosis in NAFLD and has certain diagnostic value for NAFLD.关键词
非酒精性脂肪性肝病/细胞角蛋白18/肝组织病理学/诊断Key words
Nonalcoholic fatty liver diseases/ Cytokeratin 18/ Liver histopathology/ Diagnosis引用本文复制引用
钱建成,陆璐,娄国强,荀运浩,施军平..血清细胞角蛋白18诊断非酒精性脂肪性肝病的价值探讨[J].实用肝脏病杂志,2012,15(4):291-294,4.基金项目
杭州市科技计划项目(20110833B07) （20110833B07）
杭州市医药卫生科技计划重点项目(2011Z006) （2011Z006）
