实用肝脏病杂志2012，Vol.15Issue(4)：318-320,3.DOI:10.3969/j.issn.1672-5069.2012.04.016
阿德福韦酯治疗HBV野生株与变异株混合感染患者3月疗效观察
Three month-efficacy of adefovir dipivoxil in the treatment of patients with lamivudine-related hepatitis B viral YIDD or YVDD mutant infection
摘要
Abstract
Objective To observe the 3 month-efficacy of adefovir dipivoxil in the treatment of patients with lamivudine -related hepatitis B viral YIDD or YVDD mutant infection. Methods 30 lamivudine -resistant chronic hepatitis B patients were treated by combination of adefovir dipivoxil and lamivudine in this study for three months. The serum HBV DNA was detected by fluorescent quantitation PCR. Results The HBV YIDD or YVDD mutant infection was found in 21 patients, and the mixed mutant and wild viral infection was found in 9; the baseline of serum HBV DNA, ALT and AST in mutant group were 6.2±1.4 lgcopies/ml, 139.8±153.2U/L and 119.0±32.1U/L, respectively. After 3 month treatment, they dropped to 2.3±2.31gcopies/ml, 54.5±44.7U/L and 39.8± 32.1U/L,respectively;the baseline of them in mixed infection group were 6.0±1.9 lgcopies/ml, 144.7±128.2U/L and 114.2±131.1U/L, respectively and after 3 month treatment, they dropped to 2.4±2.41gcopies/ml,55.8±53.2U/L and 42.8 ±32.3U/L, respectively (P>0.05);the HBV DNA loss in mutant infection was found in 90.5% , serum ALT normalization in 90.5% , and the HBV DNA loss and ALT normalization in mixed infection were 88.9% and 77.8% , respectively; no HBeAg seroconversion was found in mutant infection group, while 37.5% (3/8)had HBeAg seroconversion in mixed infection group. Conclusion Conbination of lamivudine and adefovir dipivoxil therapy for patients with hepatitis B mutant or mutants and wild viral infection can get the same short-term efficacy.关键词
慢性乙型肝炎/拉米夫定/阿德福韦酯/病毒变异株Key words
Hepatitis B/ Lamivudine/ Adefovir dipivoxil/ Mutation引用本文复制引用
梁佳佳,张振华,方立庆,熊自忠,魏少峰,李旭..阿德福韦酯治疗HBV野生株与变异株混合感染患者3月疗效观察[J].实用肝脏病杂志,2012,15(4):318-320,3.基金项目
安徽省光辉基金资助项目(编号:GHF-002) （编号:GHF-002）
安徽省卫生厅科研基金项目(编号:09A069 （）
2010C053) （）
