生殖医学杂志2012，Vol.21Issue(3)：209-213,5.DOI:10.3969/j.issn.1004-3845.2012.03.003
高龄孕妇胎儿唐氏综合征中孕期产前筛查和产前诊断的卫生经济学分析
Cost-effectiveness analysis of second trimester prenatal screening and diagnosis for fetal Down Syndrome in women of advanced maternal age
摘要
Abstract
Objective: To evaluate the effectiveness of prenatal serum screening and genetic amniocentesis for diagnosis of Down Syndrorpe (DS) in second trimester, and compare the cost-effect of serum screening and amniocentesis among women of advanced maternal age. Methods- A total of 5,404 pregnant women of advanced maternal age and natural singletons pregnancy for 15-20 weeks were recruited for the prospective study from Jan. 2008 to Dec. 2010. The patients were grouped by their decision into the serum screening group (2,107 patients) and the amniocentesis group (3,297 patients). The prevalence of fetal DS was compared between the two groups by chi-square test. The result of cost-effect analysis was compared between the two groups. Results: There was no statistical difference in the prevalence of fetal DS between the serum screening group and amniocentesis group (P = 0. 928) by chi-square test. The detection rate, false positive rate, false negative rate and the positive predictive rate of the screening group were 100%, 19. 63%, 0% and 4. 2% respectively. The cost-effect analysis showed that the scheme offering genetic amniocentesis for the women with positive result of serum screening would result in a significant savings of 44. 9% when compared with universal genetic amniocentesis. Conclusions: The detection efficiency of the scheme offering genetic amniocentesis for the women with serum positive screening result was as same as that of universal genetic amniocentesis, but the former scheme could save more.关键词
高龄孕妇/产前筛查/羊膜腔穿刺术/效价比Key words
Advanced maternal age/ Prenatal screening/ Genetic amniocentesis/ Cost-effectiveness引用本文复制引用
周希亚,戚庆炜,蒋宇林,边旭明,刘俊涛..高龄孕妇胎儿唐氏综合征中孕期产前筛查和产前诊断的卫生经济学分析[J].生殖医学杂志,2012,21(3):209-213,5.基金项目
国家“十一五”科技支撑计划:重大出生缺陷和遗传病的防治研究(项目编号:2006BA105A00) （项目编号:2006BA105A00）
