天津中医药2012，Vol.29Issue(2)：162-165,4.
熄风胶囊对氯化锂-匹罗卡品癫痫大鼠皮质和海马多药耐药相关蛋白1表达影响的研究
Effect ofXl Feng capsule on expression of MRP1of hippocampus and cortex in epileptic rats induced by lithium-pilocarpine
摘要
Abstract
[Objective] To sludy the intervention effect of Xi Feng capsule on medicine-related protein 1 (MRP1) of hippocampus and cortex in epileptic rats induced by Lithium-Pilocarpine. [Methods] 1 (Epilepsy was duplicated in rats with lithium-pilocarpine chemical ignition. 2)A1I the experimental rats were randomly divided into eight groups: normal control group, model group, Xi Feng intervention group(Xi Feng high-dose group), Xi Feng intervention group(Xi Feng middle-dose group), Xi Feng intervention group(Xi Feng low-dose group), Xi Feng high-dose+CBZ group, Xi Feng high-dose+CBZ 1/2 dose group, CBZ group. 3)The expression of MKP1 of hippocampus and cortex in epileptic rats was observed by Western-blot. [Results] The result of Westem-blol method suggested that there was a significant difference between intervention group of Xi Feng capsule and model group (P<0.05). [Conclusion] Xi Feng capsule single and combined with CBZ could efficiently depress the overexpression of MRP1 of the hippocampus and cortex in epileptic rats induced by Lithium-Pilocarpine.关键词
难治性癫痫/熄风胶囊/匹罗卡品/多药耐药相关蛋白1Key words
intractable epilepsy/ Xi Feng capsule/ pilocarpine/ MRP1分类
医药卫生引用本文复制引用
李新民,任艳艳,陈会,路岩莉..熄风胶囊对氯化锂-匹罗卡品癫痫大鼠皮质和海马多药耐药相关蛋白1表达影响的研究[J].天津中医药,2012,29(2):162-165,4.基金项目
天津市应用基础及前沿技术研究计划项目(08JCYBJC10900). （08JCYBJC10900）
