天津中医药2012，Vol.29Issue(2)：166-168,3.
白附子混悬液对荷瘤小鼠p16、bcl-2的表达及端粒酶活性的相关性研究
Study on correlation between suspension of white monkshood (SGTR) stimulated expression of p16,bcl-2 and telomerase activity in tumor-bearing mice
摘要
Abstract
[Objective] To explore the effect of suspension of white monkshood (SGTR) on telomerase activity and pi6, bcl-2 expression in tumor-bearing mice. [Methods] The telomerase concentration in mice serum was detected with ELJSA method. The expression of pl6 and bcl-2 protein in H22 tumor tissues was determined with immunohistochemislry method and then the effect mechanism of white monkshood on the tumor apoptosis was inferred. [Results] The expression level of pl6 gene could be up-regulated by SGTR and it had significantly difference when compared with model group (P<0. 01);the expression level of pl6 gene could be down-regulated by SGTR and it had significantly difference when compared with model group (P<0.01); the telomerase activity in tumor-bearing mice was inhibited by SGTR and it had significantly difference when compared with model group (P<0.01). [Conclusion] SGTR can performed its anti-tumor effect by inhibiting the telomerase activity, down-regulating the expression of apoptosis gene bcl-2, up-regulating the cancer suppressor gene p-16 and thereby promoting the apoptosis of tumor cells.关键词
白附子混悬液/端粒酶/p16/bcl-2Key words
SGTR/ telomerase/ p16/ bcl-2分类
医药卫生引用本文复制引用
于晓红,丛珊,梅蕾..白附子混悬液对荷瘤小鼠p16、bcl-2的表达及端粒酶活性的相关性研究[J].天津中医药,2012,29(2):166-168,3.基金项目
黑龙江省科技攻关计划资助项目(G00C201301). （G00C201301）
