天然产物研究与开发2012，Vol.24Issue(5)：599-604,6.
沙棘籽渣水提物对正常和糖尿病小鼠血糖的影响
Effects of Aqueous Extract of Seabuckthorn Seed Residues on Blood Glucose in Normal and Alloxan-induced Diabetic Mice
王捷思 1张雯 1王洁琼 1赵頔 1瞿伟菁1
作者信息
- 1. 华东师范大学生命科学学院,上海200062
- 折叠
摘要
Abstract
In present study,the effects of aqueous extract of seabuckthorn (Hippophae rhamnoides L ) seed residues (ASSR) on serum glucose and lipid profiles in normal and alloxan-induccd diabetic mice were investigated. To evaluate the safety of ASSR,we observed the acute toxic reaction of mice after intragastric administration of ASSR. Then, ASSR were orally administered to normal (250 and 500 mg/kg) and diabetic mice (250,500 and 800 mg/kg) once a day lasting for3 weeks,and the change of serum glucose, insulin, total cholesterol, triglyceride and body weight were observed to examine the effects of ASSR on serum glucose and lipid profiles. Results showed that the LD50 of ASSR was higher than 9.8 g/kg body weight ( B. W. ). Oral administration of the extract once a day for 3 weeks significantly lowered fasting serum glucose and triglyceride levels in diabetic mice,and no effect was seen in normal mice both in serum glucose and lipids levels. These results indicated ASSR has no obvious acute toxicity and possessed significant hypoglycemic and hypotriglyceridemic effects in alloxan-induced diabetic mice.
关键词
沙棘籽渣水提物(ASSR)/急性毒性试验/1型糖尿病小鼠/降血糖作用Key words
aqueous extract of seabuckthom (ASSR) /acute toxic reaction/type 1 diabetic mice/hypoglycemic effect分类
农业科技引用本文复制引用
王捷思,张雯,王洁琼,赵頔,瞿伟菁..沙棘籽渣水提物对正常和糖尿病小鼠血糖的影响[J].天然产物研究与开发,2012,24(5):599-604,6.
