天然产物研究与开发2012，Vol.24Issue(5)：648-652,5.
11-脱氧18α-和18β-甘草次酸类抗癌复合物的制备和结构表征
Preparation and Characterization of Anticancer Conjugates 11-deoxo-18α and 18β-Glycyrrhetinic Acid Derivatives
摘要
Abstract
To obtain new antieancer prodrugs on the bases of hepatocell targeting property of natural product glycyrrhetinic acid and its semi-synthetic derivatives, we prepared two conjugated products by the route of coupling 11 -deoxo-glycyrrhe-tinic acid derivatives with nitrogen mustard dichlorophosphate (the active metabolite of antieancer drug cyclophospha-mide). The structure of two target compounds and 7 intermediate products was characterized by routine spectrometric methods;the technologies of preparation and physical-chemical properties were studied.This work may provide substantial bases for further pharmacological screening of new antieancer products from glycyrrhetinic acid derivatives with hep-directing potency.关键词
11-脱氧甘草次酸类/氢化还原/构型转化/11-脱氧18α-和18β-甘甲磷酰氮芥酯/结构表征Key words
18β-glycynhetinic acid/chemical reduction/epimerization/11-deoro-18α and 18β-methy glycyrrhetinic acid-phosphorus nitrogen mustard ester/characterization分类
医药卫生引用本文复制引用
木合布力·阿布力孜,闵杰,郑大成,马红艳,热娜·卡斯木..11-脱氧18α-和18β-甘草次酸类抗癌复合物的制备和结构表征[J].天然产物研究与开发,2012,24(5):648-652,5.基金项目
国家自然科学基金项目(30960461) （30960461）
