武警医学2012，Vol.23Issue(7)：599-600,604,3.
来氟米特联合科素亚与单纯应用科素亚治疗IgA肾病的对照研究
Effect of combined leflunomide and cozaar therapy on IgA nephropathy
摘要
Abstract
Objective To study the effects of combined leflunomide and cozaar therapy on IgA nephropathy. Methods Forty patients with IgA nephropathy diagnosed by renal biopsy were randomly divided into two groups; cozaar (100 mg/d) treated group and le-flunomide(20mg/d) plus cozaar treated group. The changes in proteinuria and serum creatinine were observed. Results After 1 month treatment by the two methods, the level of proteinuria decreased significantly [(0.92+0.53) vs (1.28+1.99) ] (P <0.05) in all. After 3 and. 6 months of treatment ? the level of proteinuria in combined, leflunomide End cozaar therapy group was lower than that in cozaar therapy group(P < 0. 05). Conclusions Combined leflunomide and cozaar therapy reduces 24 h urine proteinuria and protects renal function in patients with IgA nephropathy.关键词
来氟米特/科素亚/IgA肾病Key words
leflunomide/cozaar/IgA nephropathy分类
临床医学引用本文复制引用
张建荣,张承英,耿燕秋,丁韬..来氟米特联合科素亚与单纯应用科素亚治疗IgA肾病的对照研究[J].武警医学,2012,23(7):599-600,604,3.
