外科理论与实践2012，Vol.17Issue(3)：243-247,5.DOI:10.3969/j.issn.1007-1096.2012.03.011
胰腺癌MUC4的表达及其临床相关影响因素的分析
Relationship between expression of MUC4 in pancreatic cancer and clinical factors
摘要
Abstract
Objective To analyze the relationship between the expression of MUC4 in pancreatic cancer and clinical factors. Methods The expression of MUC4 was detected in 53 cases with pancreatic cancer and the paired para-carcinoma tissues, 9 cases with chronic pancreatitis by immunohistochemical(lHC) method. The relationship between MUC4 expression and clinical characteristics, including tumor differentiation, tumor staging and survival time, was analyzed. Results IHC analysis showed positive expression of MUC4 in 43/53 (81.1%) cases with pancreatic cancer, and 2/9 (22.2%) in cases with chronic pancreatitis, and none in the paired para-carcinoma tissues. The positive rate of the MUC4 expression in pancreatic cancer was significantly higher than that in the paired para-carcinoma tissues and in chronic pancreatitis (f<0.05). No relationship was found between MUC4 expression and clinical factors such as gender, age, tumor location, tumor size, lymph node metastasis, tumor differentiation, tumor staging (P>0.05). Both univariate and multivariate analyses of survival showed that lymph node metastasis, tumor differentiation and MUC4 expression were independent prognostic factors of survival after surgery for pancreatic cancer. The higher expression of MUC4 had a poorer prognosis (P<0.05). Conclusions MUC4 might he a specific tumor marker of pancreatic cancer. Overexpression of MUC4 in pancreatic cancer may be a diagnostic marker of pancreatic cancer, and expression of MUC4 may be used as a parameter for differentiation to pancreatic carcinoma from chronic pancreatitis. It can also be considered as a prognostic factor after operation.关键词
胰腺癌/MUC4/慢性胰腺炎/预后Key words
Pancreatic cancer/ MUC4/Chronic pancreatitis/ Prognosis分类
医药卫生引用本文复制引用
王伟艺,项炜,唐文皓,袁祖荣,唐健雄,王巍,涂彦渊,丁皓,姜翀弋..胰腺癌MUC4的表达及其临床相关影响因素的分析[J].外科理论与实践,2012,17(3):243-247,5.基金项目
国家自然科学基金(30400438) （30400438）
