西北国防医学杂志2012，Vol.33Issue(3)：248-250,3.
阿仑膦酸钠对绝经后骨质疏松症患者骨密度及血清碱性磷酸酶、骨钙素的影响
Effect of alendronate sodium on serum alkaline phosphatase, osteocalcin and bone mineral density in patients with postmenopausal osteoporosis
白孟海 1白洁 2郑蓉 1陈克明 1刘茗露1
作者信息
- 1. 兰州军区兰州总医院,甘肃兰州730050
- 2. 兰州军区兰州总医院安宁分院检验科
- 折叠
摘要
Abstract
Objective: To investigate the effect of alendronate sodium on serum alkaline phosphatase (ALP), osleocalein and bone mineral density (BMD) in patienis with postmenopausal osteoporosis. Methods,- A iota! Of 62 postmenopausal women with osteoporosis were randomly divided into 2 groups: 32 treatment patients received alendronate sodium and Alpha D3 treatment, and 30 control patients received Alpha D3 only. Before treatment, 6 and 12 months after treatment, the postmenopausal BMD of anterior - posterior lumbar spines and proximal femur were determined by dual - energy X - ray abaorptiometry, and the serum alkaline phosphatase and osteocalein were detected. Results-. Compared with control group, the serum ALP and osteocalcin levels were significantly decreased 6 and 12 months after treatment (P<0.01). Compared with that before treatment, the BMD value of the lumbar spine and proximal femur wag significantly increased 12 months after treatment (P <0.05 ). There was also obvious difference in BMD level of the lumbar spine and proximal femur 12 months afiei treatment between treatment group and control group (P<0. 05). Conclusion: Alendronate sodium is effective for the patients with postmenapausai osteoporosis, which can decrease the serum ALP level and increase the serum osteocalcin level.关键词
骨质疏松/阿仑膦酸钠/绝经后/骨密度/碱性磷酸酶/骨钙素Key words
Osteoporosis/ Alendronate/ Postmenopausal/ Bone mineral density/ Alkaline phosphatase/ Osteocalcin分类
医药卫生引用本文复制引用
白孟海,白洁,郑蓉,陈克明,刘茗露..阿仑膦酸钠对绝经后骨质疏松症患者骨密度及血清碱性磷酸酶、骨钙素的影响[J].西北国防医学杂志,2012,33(3):248-250,3.
