西北师范大学学报（自然科学版）2012，Vol.48Issue(3)：111-115,5.
D-半乳糖处理小鼠抗氧化能力及肝和海马区形态学变化的研究
Research of changes in anti-oxidative ability and morphology of liver and hippocampus in mice induced by D-galactose
摘要
Abstract
To investigate the changes in anti-oxidative ability and morphology of liver and hippocampus in mice induced by D-galactose, the mice are induced by sc 1 250 rag'kg ' D-galactose for 6 weeks in the experiment. Then the total antioxidant capality (T-AOC), contents of malondialdehyde ( MDA ) and the activities of superoxide dismutase(SOD), monoamine oxidase(MAO) and glutathione peroxidase(GSH-Px) in brain, the activities of SOD, MAO and GSH-Px and the contents of MDA in liver and the plasma SOD activity and MDA level are measured respectively. Results show that the T-AOC, activities of SOD, MAO and GSH-Px and the contents of MDA in brain decrease in D-galactose treatment group (DT) ; In liver, GSH-Px activity decreases, contents of MDA increase and the SOD activity increases remarkably(P <C0. 05) in D-galactose treatment group, but SOD activity increases remarkably and the contents of MDA do not change remarkably in plasma. The liver and hippocampus morphology changes markedly in the treatment group. The mice induced by D-galactose can be used as the model for aging research.关键词
D-半乳糖/小鼠/抗氧化/肝/海马区Key words
D-galactosei mice/ anti-oxidant/ livers hippocampus分类
生物科学引用本文复制引用
刘国安,郑炜,杨红,丁兰,康文亮..D-半乳糖处理小鼠抗氧化能力及肝和海马区形态学变化的研究[J].西北师范大学学报（自然科学版）,2012,48(3):111-115,5.基金项目
教育部留学回国人员科研启动基金资助项目:甘肃省教育厅研究生导师科研基金资助项目(0901-05) （0901-05）
