中国组织工程研究2012，Vol.16Issue(27)：5103-5107,5.DOI:10.3969/j.issn.2095-4344.2012.27.031
缺血性脑损伤后内源性神经干细胞迁移机制及中医药的调节作用
Mechanism underlying endogenous neural stem cells migration following ischemic brain damage and the regulatory effect of traditional Chinese medicine
摘要
Abstract
BACKGROUND: Migration of endogenous neural stem cells (NSCs) caused by ischemic brain injury has been a spot light in neuroscience. After ischemic brain injury, neuron becomes swelling and necrotic due to ischemia and hypoxia. NSCs that migrated to the necrosis area driven by a variety of factors can repair the brain tissue and make neural function recovered partially. OBJECTIVE: To review the mechanism underlying NSCs migration caused by ischemic brain injury and the regulatory effects of traditional Chinese medicine. METHODS: A computer-based retrieval of PubMed Database, Chinese Journal Full-text Database, China Doctor Dissertations Full-text Database and China National Knowledge Infrastructure to search articles describing the mechanism underlying NSCs migration caused by ischemic brain injury and the regulatory effects of traditional Chinese medicine published from 2000 to 2011 using the key words "cerebral ischemia, endogenous neural stem cells, migration, traditional Chinese medicine". The repetitive studies were excluded. The retrieved literatures contained original articles, thesis and reviews. RESULTS AND CONCLUSION: A great number of articles have proven that NSCs migrate to the lesion site after brain injury. Factors such as cytokines, growth factors, chemotactic factors and inflammatory factors are involved in the migration of NSCs. Also, many studies have also confirmed that traditional Chinese medicine plays an important role in regulating the migration of endogenous NSCs.关键词
缺血性脑损伤/神经干细胞/迁移/中药/综述文献/干细胞分类
医药卫生引用本文复制引用
苏晓慧,孔祥英,林娜..缺血性脑损伤后内源性神经干细胞迁移机制及中医药的调节作用[J].中国组织工程研究,2012,16(27):5103-5107,5.基金项目
国家自然科学基金面上项目(30873394) （30873394）
中国中医科学院自主选题(ZZ2006105). （ZZ2006105）
