中国组织工程研究2012，Vol.16Issue(28)：5181-5184,4.DOI:10.3969/j.issn.2095-4344.2012.28.011
育亨宾、纳洛酮及两药合用对氯胺酮麻醉模型小鼠的催醒试验
Effect of yohimbine, naloxone and their combination on analepsia from ketamine-induced anesthesia in mice
摘要
Abstract
BACKGROUND: Yohimbine and naloxone are widely used as narcotic antagonists in clinic, especially against ketamine-induced anesthesia. OBJECTIVE: To investigate the analeptic effects of yohimbine, naloxone and their combination on ketamine-induced anesthesia in mice. METHODS: Forty Kunming mice were randomly assigned to four groups, and all mice were intraperitoneally administered with ketamine. One minute after loss of righting reflex, different groups were intraperitoneally injected with normal saline, yohimbine, naloxone, yohimbine+naloxone, respectively. The duration of loss righting reflex (sleeping time) was recorded. RESULTS AND CONCLUSION: Compared with the normal saline group, the sleeping time in the yohimbine, naloxone and yohimbine+naloxone groups was obviously decreased. In addition, significant difference was also observed between the single treated and combined groups. Yohimbine, naloxone and their combination can efficaciously play an antagonistic role in the narcotism of ketamine.关键词
氯胺酮/育亨宾/纳洛酮/催醒作用/麻醉模型/小鼠分类
医药卫生引用本文复制引用
陈琳,张彩丽,鞠艳敏,周振雷..育亨宾、纳洛酮及两药合用对氯胺酮麻醉模型小鼠的催醒试验[J].中国组织工程研究,2012,16(28):5181-5184,4.基金项目
江苏省高等学校大学生实践创新训练计划项目(JSS1124) （JSS1124）
南京农业大学校级实践创新训练计划项目(1117A09). （1117A09）
