中国组织工程研究2012，Vol.16Issue(28)：5227-5231,5.DOI:10.3969/j.issn.2095-4344.2012.28.020
针刺提高2型糖尿病模型大鼠胰岛β细胞胰岛素的表达
Improved effect of acupuncture on insulin expression of islet beta cells in type 2 diabetes rats
摘要
Abstract
BACKGROUND: Acupuncture for type 2 diabetes has obtained good clinical effects. OBJECTIVE: To observe the effect of acupuncture on insulin expression of islet beta cells in type 2 diabetes rats. METHODS: The diabetes model rats were randomly divided into acupuncture, rosiglitazone, model and normal control groups. Acupoints of Zusanli, Neiting and Yishu were selected in the acupuncture group for needling. Rosiglitazone (0.2 mg/kg) were given intragastrically in the rosiglitazone group. Double distilled water (2 mL/kg) was given intragastrically in the model group once daily for 4 consecutive weeks. RESULTS AND CONCLUSION: (T) Blood glucose level of the acupuncture group was significantly lowerthan that of the model and rosiglitazone groups (P < 0.05). (2) Blood lipid: Cholesterol and triglyceride of the acupuncture group were significantly lowerthan those of the model group (P < 0.05), and high-density lipoprotein cholesterol of the acupuncture group was significantly higher than that of the model group (P < 0.01). The above three indicators between the acupuncture and rosiglitazone groups had no significant difference. (3) The insulin expression of islet beta cells in the acupuncture group was significantly higher than that of the model and rosiglitazone groups (P < 0.05). @ Morphology of islet: Islet structure was incomplete and damaged, and the staining of insulin was poor in the model and rosiglitazone groups. Islet structure tended to be complete, and staining of insulin was visible in the acupuncture group. It is indicated that acupuncture can significantly increase the insulin expression and improve the function of islet beta cells in type 2 diabetes rats.关键词
针灸/2型糖尿病模型/胰岛β细胞/胰岛素表达/大鼠分类
医药卫生引用本文复制引用
孙志,马丽,韩海荣,张作记,孔令斌..针刺提高2型糖尿病模型大鼠胰岛β细胞胰岛素的表达[J].中国组织工程研究,2012,16(28):5227-5231,5.基金项目
国家自然科学基金资助项目(30772827). （30772827）
