中国组织工程研究2012，Vol.16Issue(28)：5297-5303,7.DOI:10.3969/j.issn.2095-4344.2012.28.034
心脏型脂肪结合蛋白的研究及在心脏外科的应用
Research progress of heart type fat binding protein and its application in cardiac surgery
王石雄 1李宁荫 1高秉仁2
作者信息
- 1. 兰州大学第二临床医学院,甘肃省兰州市,730000
- 2. 兰州大学第二医院,甘肃省兰州市,730000
- 折叠
摘要
Abstract
BACKGROUND: Heart-type fatty-binding protein is one of the most abundant proteins in the cytoplasm of myocardial cells, which is a marker protein for myocardial injury.
OBJECTIVE: To summarize the biology structure and function, metabolism dynamics of heart-type fatty binding protein, and their progress in clinical research and application in cardiac surgery.
METHODS: A search of PubMed and VIP databases (1983-01/2010-12) was performed by the first author for the literature of the biological structure and function of heart-type fatty-binding proteins and their application in cardiac surgery as well as other clinical applications. The keywords were "creatine kinase isoenzyme, heart fatty acid-binding protein, acute myocardial infarction, coronary artery bypass grafting" in English and in Chinese, respectivley. Unrelated articles or repetitive articles were excluded, and finally 62 articles were included in result analysis.
RESULTS AND CONCLUSION: Heart-type fatty-binding protein is a soluble protein with a low molecular weight, more specific in myocardial cytoplasm, and no or a little in normal plasma, which can quick release after myocardial damage. Heart-type fatty-binding protein has a good diagnostic value for perioperative myocardial injury after on-pump coronary artery bypass, and it is a potential indicator in the rapid assessment of myocardial injury induced by cardiopulmonary bypass valve replacement surgery as soon as possible. Elevated levels of heart-type fatty-binding proteins can be earlier to judge the severity of myocardial injury and to determine the degree of impaired cardiac function and heart-related complications.关键词
心脏型脂肪结合蛋白/心脏外科/心肌梗死/肺栓塞/心肌炎/综述文献分类
医药卫生引用本文复制引用
王石雄,李宁荫,高秉仁..心脏型脂肪结合蛋白的研究及在心脏外科的应用[J].中国组织工程研究,2012,16(28):5297-5303,7.
