中国组织工程研究2012，Vol.16Issue(29)：5379-5383,5.DOI:10.3969/j.issn.2095-4344.2012.29.013
异种松质骨修复兔桡骨节段性骨缺损
Xenogeneic cancellous bone for repairing segmental bone defects in rabbit radius
摘要
Abstract
BACKGROUND: Xenogeneic cancellous bone has a natural porous structure that facilitates the ingrowth of new bone. Besides, its antigenicity can be eliminated completely after treatment and cannot induce immune rejection. Moreover, it has good bone conduction. OBJECTIVE: To evaluate the effect of xenogeneic bone on the repair of segmental bone defects in rabbit radius. METHODS: Totally 36 rabbits (4-6 months old, 2.5-3.5 kg, no gender limitations) were randomly divided into three groups: experimental group, control group and blank group. A rabbit model of 15 mm-long segmental bone defects in the radius was established. Rabbits in the experimental group were implanted with biological xenogeneic bone, and those in the control group were implanted with deep frozen allogenic bone, while the blank group had no treatment. At weeks 4, 8 and 12 after operation, rabbits in the three groups were observed by general observation, anatomy observation, X-ray examination and histological examination. RESULTS AND CONCLUSION: At weeks 4, 8 and 12 after operation, bone defects in the experimental and control groups were repaired gradually, but no repair was found in the blank group. The radiographic and histological scores were both higher in the experimental and control groups than the blank group (P < 0.05). The radiographic and histological scores between the experimental and control groups had no significant difference. These results suggest that biological xenogeneic bone is good to repair bone defects; in addition, the repair effect of biological xenogeneic bone is the same as that of xenogeneic bone.关键词
异种骨/异体骨/骨缺损/再血管化/骨愈合/兔/生物材料分类
医药卫生引用本文复制引用
魏冀荣,章莹,林永亮..异种松质骨修复兔桡骨节段性骨缺损[J].中国组织工程研究,2012,16(29):5379-5383,5.基金项目
广东冠昊生物科技股份有限公司及其动物中心对本实验提供资金和技术支持,课题名称:骨诱导型可降解吸收生物活性骨修复材料产业化,项目类型:2008年度广州市生物产业重大专项项目(2008A1-E4051). （2008A1-E4051）
