中国组织工程研究2012，Vol.16Issue(30)：5569-5576,8.DOI:10.3969/j.issn.2095-4344.2012.30.013
骨靶向亲和性引经药防治原发性骨质疏松症
Effect of bone targeted affinity medicinal guiding in preventing and treating primary osteoporosis
摘要
Abstract
BACKGROUND: The theory of "kidney is in charge of the bones" is in line with the mechanism of bone metabolic regulation in modern medicine, the tonifying kidney prescriptions made according to the bone targeted affinity and medicinal guiding of cell signal transduction has effective action for osteoporosis, but further researches should focus on the action mechanism of the compatibility ratio of high dose and low dose guiding drugs at skeleton formation. It can clarify the two arguments about application of high dose and low dose guiding drugs by observing osteoporosis relevant specific indexes in clinic. OBJECTIVE: To investigate the correlation between target-oriented administration and drug own selectivity target-tropism special guiding carrier structure by comparing the treatment effects of the channel tropism functions of prescription for kidney tonifying of the compatibility ratio of high dose and low dose guiding drugs on primary osteoporosis of the channel and collaterals according to diagnosis. METHODS: The 180 patients with osteoporosis were randomly divided into six groups: high dose guiding drugs for kidney meridian group (HKG), low dose guiding drugs for kidney meridian group (LKG), high dose guiding drugs for liver meridian group (HLG), low dose guiding drugs for liver meridian group (LLG), high dose guiding drugs for spleen meridian group (HSG), low dose guiding drugs for spleen meridian group (LSG) with 30 cases in each group. Patients in HKG, HLG and HSG were given 20 g Achyranthes bidentata Bl versus 10 g Kang Gu Song Dan Qi instant granules every time respectively, three times daily for successive 6 months. Patients in LKG, LLG and LSG were given 20 g Achyranthes bidentata Bl versus 10 g Kang Gu Song Dan Qi instant granules every time, three times daily, six months as one course of treatment, and no other anti-osteoporosis treatment was performed during administration. The curative effect was evaluated by observing bone ache symptoms and changes in bone mineral density of lumbar vertebrae, serum calcium, alkaline phosphatase, bone gla protein, urinary hydroxyproline, urine calcium, urine creatinine, estradiol and testosterone. RESULTS AND CONCLUSION: High dose guiding drugs versus Kang Gu Song Dan Qi instant granules could treat primary osteoporosis of the channel and collaterals according to diagnosis. It could obviously increase the bone mineral density of lumbar vertebrae and the alleviating rate of ostealgia, and without any related adverse effect. Prescription for tonifying kidney of the compatibility ratio of high dose and low dose guiding drugs has effects on treating the primary osteoporosis, and the effect of the former is better than the latter.关键词
骨靶向亲和性/原发性骨质疏松/引经药/骨密度/骨代谢/经络辨证分类
医药卫生引用本文复制引用
武密山,武博文,任立中,王茹,白霞,韩红伟,李彬,赵素芝..骨靶向亲和性引经药防治原发性骨质疏松症[J].中国组织工程研究,2012,16(30):5569-5576,8.基金项目
国家自然科学基金资助项目(81073074)《骨靶向亲和性引经药与"肾主骨"信号转导相关性研究》 （81073074）
国家自然科学基金资助项目(30472200)《补肾方药的归经与特异性转录因子相关性研究》 （30472200）
河北省引进留学人员经费资助项目(200828)《补肾方药组分配伍与骨质疏松作用靶点相关性的研究》. （200828）
