中国组织工程研究2012，Vol.16Issue(31)：5742-5746,5.DOI:10.3969/j.issn.2095-4344.2012.31.010
血管内皮生长因子与碱性成纤维细胞生长因子联合应用对自体游离脂肪颗粒移植成活的影响
Effect of vascular endothelial growth factor and basic fibroblast growth factor on the survival of autologous free fat particles after transplantation
摘要
Abstract
BACKGROUND: The micro-angiogenesis is the key to the survival of the fat cells. Research shows vascular endothelial growth factor and basic fibroblast growth factor can promote blood vessel growth. OBJECTIVE: To observe the effect of vascular endothelial growth factor and basic fibroblast growth factor on the survival of fat particles after transplantation. METHODS: Fifty SD rats were divided into five groups, and the autologous greater omentum was transplanted to the rat back, and then added normal saline, 50 ug/L vascular endothelial growth factor, 50 ug/L basic fibroblast growth factor, 50 ug/L vascular endothelial growth factor+50 ug/L basic fibroblast growth factor and 100 ug/L vascular endothelial growth factor+100 ug/L basic fibroblast growth factor, respectively. At 15 and 30 days after transplantation, rats were killed to remove the graft. RESULTS AND CONCLUSION: The graft residual weight and vascular density in 100 ug/L vascular endothelial growth factor+100 ug/L basic fibroblast growth factor experimental group was significantly higher than those in the other three groups and the difference was significant (P < 0.05), there was no significant difference among the other four groups (P > 0.05). The combination of vascular endothelial growth factor and basic fibroblast growth factor can significantly promote the fat particles to survive.关键词
大网膜/脂肪颗粒/血管内皮生长因子/碱性成纤维细胞生长因子/联合应用分类
医药卫生引用本文复制引用
杨林,岳毅刚..血管内皮生长因子与碱性成纤维细胞生长因子联合应用对自体游离脂肪颗粒移植成活的影响[J].中国组织工程研究,2012,16(31):5742-5746,5.基金项目
广西自治区卫生厅自筹经费科研课题(合同号z2007217). （合同号z2007217）
