中国组织工程研究2012，Vol.16Issue(31)：5828-5832,5.DOI:10.3969/j.issn.2095-4344.2012.31.027
肾衰泻浊汤对肾衰竭大鼠内皮细胞损伤的保护
Protective effect of Shenshuai Xiezhuo decoction on endothelial cells damage in rats
摘要
Abstract
BACKGROUND: The clinical treatment by Shenshuai Xiezhuo decoction is mainly depending on eliminate turbid fluid and remove toxic and invigorating spleen and kidney. OBJECTIVE: To investigate the protective effects of Shenshuai Xiezhuo decoction on endothelial cells damage of chronic renal failure (CRF) rats and the regulation effect on the expression of vascular endothelial growth factor (VEGF) receptor. METHODS: Sixty Wistar rats were randomly divided into control group, model group, low-dose group, middle-dose group, high-dose group and Cozaar group. The rats in the last five groups were used to establish the CRF model induced by adenine induction; rats in the low-dose group, middle-dose group and high-dose group were gavaged with 6, 12 and 24 g/(kgd) Shenshuai Xiezhuo decoction; rats in the losartan potassium group were injected with losartan potassium. RESULTS AND CONCLUSION: Compared with the model group, the content of serum creatinine (SCr), blood urea nitrogen, p2-microglobulin (MG), urine micro-albumin (mALB), serum soluble intercellular adhesion molecule 1 (slCAM-1), VEGF, von willebrand factor M (VWF) and the kidney index in the treatment groups were decreased significantly (P < 0.05), and there was a positive correlation between with P2MG, mALB, SCr and urea nitrogen. Evident alleviation of nephridial tissue injury was appeared in the treatment groups, especially in the middle-dose group and the losartan potassium group. Shenshuai Xiezhuo decoction is effective on decreasing the content of SCr, urea nitrogen, P2MG and mALB, and can delay the chronic renal failure. The mechanism may relate with regulating the content of slCAM-1, VEGF and VWF.关键词
肾衰泻浊汤/血管内皮生长因子/慢性肾衰竭/肌酐/尿素氮/β2-微球蛋白分类
医药卫生引用本文复制引用
杨军平,邱丽瑛,魏固伟,文娟..肾衰泻浊汤对肾衰竭大鼠内皮细胞损伤的保护[J].中国组织工程研究,2012,16(31):5828-5832,5.基金项目
江西省教育厅科技项目(赣教技字[2007]258). （赣教技字[2007]258）
