中国组织工程研究2012，Vol.16Issue(31)：5853-5860,8.DOI:10.3969/j.issn.2095-4344.2012.31.032
免疫抑制剂用于角膜移植排斥反应的临床应用评价
Clinical application of immunosuppressive agents in corneal graft rejection
王洋 1刑春生 2周星 1王磊 1韩宏光3
作者信息
- 1. 沈翔705医院眼科,辽宁省沈阳市,110015
- 2. 辽宁省军区门诊部,辽宁省沈阳市,110032
- 3. 解放军沈阳军区总医院心血管外科,辽宁省沈阳市,110016
- 折叠
摘要
Abstract
BACKGROUND: Immune rejection of corneal transplantation is a complex reaction, typically including leukocyte antigen sensitization and host response to allogeneic tissue antigens. The failure of corneal transplantation is mainly due to immune rejection. Effective prevention of corneal allograft rejection in the eye treatment is a practical problem to be solved.
OBJECTIVE: To analyze the application of immunosuppressive agents in corneal graft rejection.
METHODS: A retrieval was performed for articles addressing the application and effect of immunosuppressive agents in corneal graft rejection, using key words of "keratoplasty/corneal transplantation, immunological rejection, immunosuppressant, cyclosporine A, tacrolimus, rapamycin" in Scopus database (2002/2011).
RESULTS AND CONCLUSION: Immune rejection involves multiple factors. High-risk corneal diseases, such as high-vascularized cornea, infectious corneal ulcer, repeat transplantation, particularly increase the probability of rejection and result in an earlier occurrence of rejections, moreover, the time span is longer after surgery. Corneal transplantation rejection is a complex process, and we have made progress in its prevention and treatment. However, the rejection is still the leading cause of corneal graft failure. The experts are constantly trying to apply the new drugs and treatment measures to improve the corneal graft survival, in order to make the receptor to maintain a normal immune response inducing or establishing donor-specific immune tolerance. Immunosuppressive agents in corneal graft rejection are indispensable. This paper provides a valuable reference for researchers to understand the overview and present situation of this field.关键词
角膜移植/免疫排斥反应/免疫抑制剂/环孢素A/他克莫司/雷帕霉素/文献计量分类
医药卫生引用本文复制引用
王洋,刑春生,周星,王磊,韩宏光..免疫抑制剂用于角膜移植排斥反应的临床应用评价[J].中国组织工程研究,2012,16(31):5853-5860,8.
