摘要
Abstract
Objective To observe the effect of clopidogrel on high sensitive C-reactive protein ( hs-CRP ) and tumor necrosis factor-a ( TNF-a ) in patients with acute coronary syndrome ( ACS ) after percutaneous coronary intervention( PCI ). Methods 72 patients with ACS and PCI were randomly divided into two groups, patients in control group ( 35 cases ) took 300 mg aspirin for the first time, then 100 mg aspirin every day, whereas patients in combination group ( 37 cases ) took 300 mg aspirin and 300 mg clopidogrel for the first time, then 100 mg aspirin and 75 mg clopidogrel every day. 2 groups were treated for 6 months. hs-CRP and TNF-a were examined before taking medicine in all patients 10 and 30 days after taking medicine separately; prothrombin time ( PT ), activated partial thromboplastin time ( APTT ) and platelet count ( PLT ) were examined before taking medicine, 30 days after taking medicine separately; the occurrence of cardiovascular events and adverse drug reactions within six months were observed. Results The hs-CRP, TNF-a of two groups on 10 days, 30 days after treatment were decreased than before treatment ( P <0.05 or P <0. 01 ); the hs-CRP, TNF-a in the combination group on 10 days, 30 days after treatment were decreased in combination group than that in the control group ( P < 0. 05 or P < 0. 01 ); the incidence of cardiovascular events within 6 months in the combination group was significantly lower than that in the control group ( 2. 7% vs 22. 9% , P <0. 05 ); there was no significant difference of PT, APTT and PLT between two groups before treatment and 30 days after treatment ( all P > 0. 05 ); the incidence of bleeding within 6 months was no significant difference between two groups ( 16. 2% ,8. 6% , P >0. 05 ). Conclusion Clopidogrel can reduce the level of inflammation factors, reduce cardiovascular events. The anti-inflammatory effect of clopidogrel and aspirin were significantly stronger than that of single aspirin without increase the patient bleeding events.关键词
急性冠脉综合征/经皮冠状动脉介入治疗/氯吡格雷/阿司匹林/超敏C反应蛋白/肿瘤坏死因子-αKey words
Acute coronary syndrome / Percutaneous coronary intervention / Clopidogrel/ Aspirin/ High sensitive C-reactive protein/ Tumor necrosis factor-a
