疑难病杂志2012，Vol.11Issue(8)：594-596,3.DOI:10.3969 / j.issn.1671-6450.2012.08.010
多药耐药基因多态性及其表达物与抗癫痫药疗效的相关性研究
The relationship between genetic polymorphism and expressed matter of MDR1 gene with efficacy of carbamazepine
杨美兰 1李涛 1黄映华 1陈雪云1
作者信息
- 1. 518003,深圳市第四人民医院神经内科
- 折叠
摘要
Abstract
Objective To investigate the genotypes and expressed matter of C3435T of MDR1 in peripheral blood of patients with epilepsy, and to analyze the relationship between the genetic polymorphism of MDR1 gene with the efficacy of car-bamzepine( CBZ ). Methods Forth-nine epilepsy patients who took CBZ were enrolled, according to the blood concentration of CBZ and observation of efficacy, the patients were divided into intractable epilepsy group( IE group,23 cases )and non intractable group( NIE group, 26 cases ). The C3435T polymorphism was analyzed by the polymerase chain reaction restriction fragment length polymorphism ( PCR RFLP ) method. The expression of serum Pgp was detected with flow cytometer. The blood concentration of CBZ and genotypes in IE group and NIE group was compared. 28 health)' volunteer was enrolled as control group. Results The expression of serum Pgp in the IE group ( 3. 6% ±0. 3% ) was obviously higher than that in NIE group ( 2. 6% ±0. 5% ) and health)' control group ( 2. 3% ± 0. 4% ), and the difference was statistical significance ( P < 0. 05 ). The differences of genotypes in the both groups were not statistical significance ( P > 0. 05 ). Conclusion No relationship was proved between the 3435T genetic polymorphism of MDR1 gene and the efficacy of CBZ in patients with epilepsy.关键词
癫痫/MDR1 C3435T/基因多态性/P-糖蛋白/卡马西平Key words
Epilepsy/ MDR1 gene/ C3435T/ Genetic polymorphism/ P-glycoprotein/ Carbamzepine引用本文复制引用
杨美兰,李涛,黄映华,陈雪云..多药耐药基因多态性及其表达物与抗癫痫药疗效的相关性研究[J].疑难病杂志,2012,11(8):594-596,3.
