湖北医药学院学报2012，Vol.31Issue(1)：17-21,5.
脑电双频指数引导下不同剂量右美托咪啶用于术后ICU患者镇静
Bispectral Index-guided Sedation with Different Doses of Dexmedetomidine in ICU Patients
摘要
Abstract
ObJ6CtlV6 To evaluate the postoperative efficacy and safety of Bispectral index (BIS) -guided sedation with different doses of Dexmedetomidine (Dex) . Methods Sixty ICU patients of postoperation on mechanical ventilation for at least 24 hour were randomized double blindly into group Dexl, group Dex2 and group M. The BIS, Ramsay score, MAP and HR were monitored, before Dex or Mid infusion and at each point in three hours after continuous infusion. The level of BIS was kept at 61 - 84 and used as criteria to speed up or stop the infusion to maintain sedation. The intermittent injection of Morphine (Mor) was adjusted according to the degree of the pain. Recorded mechanical ventilation time, extubation time, wake time, the changes of MAP and HR, the doses of Mor among three groups. The cases of Steward awakening score and adverse events such as delirium occurred after extubation of all patients was evaluated and recorded. Results Among the three groups, there were no significantly differences in the sedative effects (P > 0.05). The two groups of giving Dex were easier to wake up and keep quiet. The BIS decreased (P < 0.05 ) and Ramsay score was higher (P < 0.01) significantly compared with that before. At the same level of sedation, in group Dexl and Dex2, compared with group M, the wake time decreased significantly (P < 0.05) and the extubation time also decreased (P < 0.01) , after extubation Steward higher ( P <0.05) , the incidences of delirium and sleeping again decreased significantly, so were the doses of Mor. Conclusion Hie BIS guided with Dex may provide safe and effective sedation,the high quality of wake up and reduced adverse reactions such as delirium, the higher doses of Dex is more suitable for ICU patients.关键词
右美托咪啶/咪达唑仑/脑电双频指数/镇静Key words
Dexmedetomidine/Midazolam/Bispectral index/Sedation分类
医药卫生引用本文复制引用
郑敏,薛锐,冉然,刘勇,邱桂华,王群..脑电双频指数引导下不同剂量右美托咪啶用于术后ICU患者镇静[J].湖北医药学院学报,2012,31(1):17-21,5.基金项目
湖北省十堰市科学技术研究与开发项目(2011066). （2011066）
