摘要
Abstract
Objective To investigate the effect of penehyclidine hydrochloride on gastrointestinal injury in patients during cardiopulmonaiy bypass (CPB). Methods Fifty patients undergoing mitral valve replacement were randomly divided into two groups:group A(control group) and group B(penehyclidine group). In group B,penehyclidine hydrochloride 0.06 mg/ kg was given before CPB,whereas group A received placebo. Gastric intramucosal pH value(pHi) ,blood diamine oxidase ( DAO),blood D- lactic acid and blood lipopoly saccharide( LPS) were measured before injection (Tl), at the moment of reperfusion(T2) , at 1 h(T3) ,3h(T4) ,6 h(T5)after reperfusion. Result In both groups, the levels of pHi decreased significantly at T2, T3, T4, 15 than Tl (P<0.01),However in group B ,pHi at T2, T3, T4, TS was higer than that in group A (P<0.01). In both groups, the levels of DAO, blood D-lactic, LPS were higher significantly at T2, T3, T4.T5 than Tl (P <0.01),in group B,those at T2, T3, T4, T5 was lower than that in group A (P <0.01). Conclusion Penehyclidine hydrochloride can improve the level of pHi .decrease the level of DAO, D- lactic, LPS during CBP, protect structure of gastrointestinal tract mucosal cell and its barrier function.关键词
戊乙奎醚/体外循环/胃肠道Key words
Penehyclidine hydrochloride/Cardiopulmonary bypass/Gastrointestinal tract分类
医药卫生
