中国病理生理杂志2012，Vol.28Issue(7)：1197-1201,5.DOI:10.3969/j.issn.1000-4718.2012.07.009
P-选择素对ApcMin/+小鼠肠道肿瘤的作用
Role of P-selectin in intestinal tumorigenesis in ApcMin/+ mice
摘要
Abstract
ADM: To investigate the role of P ?selectin in intestinal tumorigenesis in Ape Min/+ mice ( C57BL/ 6J -ApcMin/J ). METHODS: Female P - selectin knockout mice ( B6. 129S7 - Selptml Bay/J, that was P - selectin-/- ) were mated with male ApcMin/+ mice. The offspring was genotyped for Min+/- and P -selectin null mutantions, which were ApcMin/+ P - selectin-/- ~ mice. The tumor number and gross tumor volume in the small and large intestines of the ApcMin/ + P - selectin -/- mice and ApcMin/ + mice were determined. RESULTS: P - selectin deficiency in ApcMin/ + mice resulted in significant decreases in the tumor number and gross tumor volume in the small intestine and total intestine. CONCLUSION : Deletion of P - selectin significantly inhibits the tumorigenesis in mouse intestines. In addition, the results also suggest that P - selectin may be a marker for colon cancer.关键词
P-选择素/基因工程小鼠/肠道肿瘤Key words
P - selectin/ Genetically engineered mice/ Intestinal neoplasms分类
医药卫生引用本文复制引用
郭四美,亓翠玲,叶杰,周秦,王丽京..P-选择素对ApcMin/+小鼠肠道肿瘤的作用[J].中国病理生理杂志,2012,28(7):1197-1201,5.基金项目
科技部"973"项目国家重点基础研究发展计划(No.2010CB529702) （No.2010CB529702）
国家青年基金资助项目(No.30900764) （No.30900764）
