中国病理生理杂志2012，Vol.28Issue(7)：1323-1325,3.DOI:10.3969/j.issn.1000-4718.2012.07.032
脑数字减影血管造影术对血浆ET-1和vWF水平的影响
Changes of plasma endothelin-1 and von Willebrand factor in patients undergoing cerebral digital substration angiography
摘要
Abstract
AIM: To investigate the effects of cerebral digital substration angiography( DSA ) on the expression of endothelin — l( ET — 1 ) and von Willebrand factor( vWF ) in vascular endothelial cells from the patients with ischemic cerebrovascular disease. METHODS: The plasma levels of ET — 1 and vWF were measured by enzyme — linked immu-nosorbent assay in 108 patients before, immediately and 24 h after cerebral DSA. RESULTS: The plasma level of endothelin - 1 significantly increased immediately[ ( 550. 19 ± 108. 06 )ng/L ] and 24 h[ ( 517. 26 ± 111. 84 )ng/L ] after cerebral DSA as compared with that before the procedure[ ( 501. 20 ± 111. 86 )ng/L ]( P <0. 05 ). The level of vWF was not changed before and after operation. CONCLUSION: The marked and sustained increase in endothelin - 1 plasma level after cerebral DSA is probably related to mechanical endothelial injury by the procedure of cerebral DSA.关键词
血管造影术,数字减影/内皮缩血管肽-1/von Willebrand因子Key words
Angiography, digital substration/ Endothelin - 1/ von Willebrand factor分类
医药卫生引用本文复制引用
付棉,秦超,程道宾,赵伟佳,梁志坚,刘竞丽,梁明辉,陈相任..脑数字减影血管造影术对血浆ET-1和vWF水平的影响[J].中国病理生理杂志,2012,28(7):1323-1325,3.基金项目
广西科学研究与技术开发计划项目(No.桂科攻0322025-8) （No.桂科攻0322025-8）
