中国当代儿科杂志2012，Vol.14Issue(6)：422-425,4.
小儿先天性心脏病介入治疗后心肌损伤和炎症反应的研究
Myocardial injury and inflammatory response after interventional therapy in children with congenital heart disease
摘要
Abstract
Objective To study myocardial injury and inflammatory response within 7 days after interventional therapy in children with congenital heart disease (CHD). Methods A total of 77 children with CHD, including 12 cases of ventricular septal defect (VSD), 14 cases of atrial septal defect (ASD), 14 cases of pulmonary stenosis (PS) and 37 cases of patent ductus arteriosus (PDA), were enrolled. The levels of myocardial enzyme (AST, CK and CKMB), cardiac troponin I (cTnl) and CRP in serum were measured before operation, immediately after operation, and 6 hrs, 24 hrs, 72 hrs and 7 days after operation. Results Serum AST levels in the VSD group were significantly higher than the other CHD groups immediately after operation, and 6 hrs and 24 hrs after operation (P < 0.05). There were significant differences in serum CK and CKMB levels among the four CHD groups immediately and 6 hrs after operation (P < 0. 05), and the highest serum CK and CKMB levels were found in the VSD group. Serum CRP levels in the PDA group were significantly higher than the other CHD groups 72 hrs and 7 days after operation (P<0.05). Compared with before operation, serum AST levels increased significantly in all four CHD groups 6 and 24 hrs after operation groups (P < 0.05 ). Serum CK and CKMB levels increased significantly in the VSD group immediately and 6 hrs after operation (P < 0. 05). Serum cTnl levels increased significantly in the VSD, PDA and PS groups immediately and 6 hrs after operation (P < 0. 05). The PDA group showed increased CRP levels 24 hrs, 72 hrs and 7 days after operation (P < 0. 05). Conclusions Minor myocardial injury can be noted within 7 days after interventional therapy in children with CHD and mainly occurs between immediately and 24 hrs after operation. The injury is more significant in VSD cases. The interventional therapy does not cause significant inflammation.关键词
先天性心脏病/介入治疗/心肌损伤/炎症反应/儿童Key words
Congenital heart disease/ Interventional therapy/ Myocardial injury/ Inflammatory response/ Child分类
医药卫生引用本文复制引用
江荣,黄晓碧,赵胜,李梅,刘凤,李林,杨贵明,汪泽龙,余东,黄丽华..小儿先天性心脏病介入治疗后心肌损伤和炎症反应的研究[J].中国当代儿科杂志,2012,14(6):422-425,4.基金项目
安徽省卫生厅课题(批准号09C200). （批准号09C200）
