中国当代儿科杂志2012，Vol.14Issue(6)：431-433,3.
反复肺炎婴幼儿血清β-防御素-1和免疫球蛋白A、G、M水平的研究
Serum levels of human β-defensins 1 and immunoglobulins A, G and M in infants with recurrent pneumonia
摘要
Abstract
Objective To study the possible role of human p-defensins 1 (hBD-1) and immunoglobulins A, C and M (IgA, IgG and IgM ) in the development of recurrent pneumonia by measuring serum concentrations of the above indexes in infants with recurrent pneumonia and healthy infants. Methods Serum samples were obtained from 35 healthy children and 35 children aged from 2 to 24 months with recurrent pneumonia. Serum hBD-1 concentration was measured using ELISA. Serum IgA, IgG and IgM concentrations were measured by immunonephelometry. The correlation of hBD-1 with IgA, IgG and IgM was evaluated. Results The serum concentration of hBD-1 in infants with recurrent pneumonia (14 ± 11 μg/mL) was significantly lower than in controls ( 18 ±11 μg/mL) ( P < 0. 05 ) , as was the serum concentration of IgA in infants with recurrent pneumonia (1.3 ±0.6 g/L vs 1.5 ±0.8 g/L; P < 0. 05 ). The serum concentration of IgG in infants with recurrent pneumonia was also significantly lower than in controls (9 ±3 g/L vs 13 ±5 g/L;P<0.05). There were no linear relationships between serum hBD-1 and IgA, IgG and IgM (P > 0. 05). Conclusions The serum levels of hBD-1, IgA and IgG decrease in infants with recurrent pneumonia, suggesting disorders in the immune defensive function of the respiratory tract, and this may be one of the immunity related reasons for recurrent pneumonia in infants. It is of great clinical value to measure serum levels of hBD-1, IgA, IgG and IgM in infants with recurrent pneumonia.关键词
反复肺炎/β-防御素-1/免疫球蛋白/婴幼儿Key words
Recurrent pneumonia/ Human β-defensins 1/ Immunoglobulin/ Infant分类
医药卫生引用本文复制引用
张涛,廖嘉仪..反复肺炎婴幼儿血清β-防御素-1和免疫球蛋白A、G、M水平的研究[J].中国当代儿科杂志,2012,14(6):431-433,3.基金项目
广州市医药卫生科技项目(项目编号2009-YB-177). （项目编号2009-YB-177）
