中国动脉硬化杂志2012，Vol.20Issue(4)：300-303,4.
二苯乙烯苷对H2O2诱导的血管内皮细胞P选择素和E选择素表达的影响
Effect of TSG on Expression of E-Selectin, P-Selectin in Vascular Endothelial Cell Induced by H2O2
摘要
Abstract
Aim To study the effect of 2,3,5,4'-tetrahydroxystnbene-2-O-|3-D-gHira>side (TSG) on expression of adhesion molecules P-selectin, E-selectin induced by H2O, in human umbilical vein endothelial cells. Methods The expression of P-selectin, E-selectin mRNA and protein were detected by reverse transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) respectively. Results Treating endothelial cells with 200 u.mol/L H2O2, the expression of E-selectin, P-selectin mRNA and protein level were significantly higher (P<0.01). Pretreated with TSG for 4 h, the expression of P-selectin, E-selectin mRNA and protein induced by H2O2 were significantly inhibited in endothelial cells ( P < 0.05). Conclusions TSG probably can protect human umbilical vein endothelial cells from oxidative stress by decreasing expression of adhesion molecules.关键词
二苯乙烯苷/内皮细胞/动脉粥样硬化/P选择素/E选择素Key words
2,3,5,4'-Tefrahydroxystilbene-2-O-p-D-Glucoside/Endothelial Cells/Atherosclerosis/P-Selec-tin/E-Selectin分类
医药卫生引用本文复制引用
张彩平,丁岚,田英,周永强,龙石银,田汝芳,韩瑛..二苯乙烯苷对H2O2诱导的血管内皮细胞P选择素和E选择素表达的影响[J].中国动脉硬化杂志,2012,20(4):300-303,4.基金项目
国家自然科学基金(30800474)资助 （30800474）
湖南省科技厅项目(2010SK3037)、湖南省教育厅重点项目(11A104)和湖南省研究生创新项目(CX2010B385,CX2011B378)资助 （2010SK3037）
