中国肺癌杂志2012，Vol.15Issue(4)：202-207,6.DOI:10.3779/j.issn.1009-3419.2012.04.02
TIMP-3和mtp53在非小细胞肺癌中的表达及意义
Expressions and Significance of TIMP-3 and mtp53 in Non-small Cell Lung Cancer
摘要
Abstract
Background and abjective Tissue inhibitor of metalloproteinase-3 (TIMP-3) can regulate tumor infiltration and metastasis through multiple channels and is likely associated with mutant-type p53 (mtp53). This study detected the expressions of TIMP-3 and mtpS3 in non-small cell lung cancer (NSCLC) and lymph node metastasis using tissue microarray and evaluated their significance. Methods TIMP-3 and mtp53 expressions were detected in 288 cases of NSCLC (NSCLC group), 106 cases of metastatic carcinoma in lymph nodes (metastasis group), and 24 cases of benign lesions in the bronchial mucosa epithelium (control group) by immunohistochemical staining (LSAB and Elivision). Results The expression of TIMP-3 in the NSCLC and metastasis groups was lower than that in the control group (P<0.00l), but the reverse was true for the expression of mtp53 (P<0.001). TIMP-3 and mtp53 expressions differed between NSCLC with (P=0.01S) and without (P=0.030) lymph node metastasis. TIMP-3 expression correlated with NSCLC grade (P=0.030), whereas mtpS3 expression correlated with TNM stage (P=0.016) and NSCLC histological type (P=0.004). Moreover, the expressions of TIMP-3 and mtpS3 were negative in NSCLC cases (P=0.008) and correlated with patient survival (P=0.011 and P=0.003, respectively). Conclusion Low expression of TIMP-3 and high expression of mtpS3 in NSCLC can promote tumor metastasis and inhibit each other. TIMP-3 and mtpS3 are promising targets for studying the metastatic mechanism of NSCLC.关键词
肺肿瘤/TIMP-3/mtp53/组织芯片/预后Key words
Lung neoplasms/ TIMP-3/ mtpS3/ Tissue microarray/ Prognosis分类
医药卫生引用本文复制引用
杨红,李婕,郭嘉,张尚福..TIMP-3和mtp53在非小细胞肺癌中的表达及意义[J].中国肺癌杂志,2012,15(4):202-207,6.基金项目
本课题受国家“十一五”科技攻关课题(No.2006BAI02A01)资助 （No.2006BAI02A01）
