中国肺癌杂志2012，Vol.15Issue(6)：340-347,8.DOI:10.3779/j.issn.1009-3419.2012.06.04
甘氨双唑钠对非小细胞肺癌放射治疗增敏作用的Meta分析
A Meta Analysis of Radiosensitivity on Non-small Cell Lung Cancer by Metronidazole Amino Acidum Natrium
摘要
Abstract
Background and objective The efficacy and safety of radiosensitivity on non-small cell lung cancer (NSCLC) using metronidazole amino acidum natrium (CMNa) are yet to be proven. This study evaluates the efficacy and safety of radiosensitivity on NSCLC by CMNa to provide references for further clinical practice and research. Methods Relevant randomized controlled trials (RCTs) were obtained from the Cochrane library, Pubmed, EMbase, CBM, CNKI, VIP, and Wan Fang databases. Dates were searched through other means. RCTs of radiosensitivity on NSCLC by CMNa were included. The data included in the study were evaluated and analyzed using the Cochrane Collaborations RevMan S. 1 software. Results A total of 21 RCTs were included. The results of the meta-analyses showed that the total effective rate of the test group that received CMNa plus radiotherapy was higher than that of the control group that received radiotherapy alone (OR=3.29,95%C1: 2.47-4.39, P<0.000,0l) or radiotherapy plus placebo (OR=3.6S, 9596CI: 2.25-5.92, P<0.000,O1), respectively. No significant differences were found in the quality of life between one and two-year survival rates (P>0.05). No significant differences were found among radiation pneumonitis, radiation esophagitis, hematological toxicity, and cardiotoxicity (P>0.05). Conclusion CMNa plus radiotherapy elicit beneficial effects in the treatment of NSCLC and produce fewer adverse effects. Therefore, this technique can be recommended and applied in clinics.关键词
肺肿瘤/放射治疗/放射增敏剂/Meta分析/RCTKey words
Lung neoplasms/ Radiotherapy/ Radiosensitizer/ Mela-analysis/ Randomized controlled trial分类
医药卫生引用本文复制引用
任维维,李征,米登海,杨克虎,田金徽,张质钢..甘氨双唑钠对非小细胞肺癌放射治疗增敏作用的Meta分析[J].中国肺癌杂志,2012,15(6):340-347,8.基金项目
本研究受甘肃省卫生行业科研计划项目(No.GSWST09-06)、甘肃省自然科学研究基金项目(No.1010RJZA162)、兰州大学循证医学中心循证医学研究生创新基金(No.2010LDEBM-A)资助 （No.GSWST09-06）
