中国临床药理学与治疗学2012，Vol.17Issue(3)：274-279,6.
γ-氨基丁酸信号在JAR细胞中的表达及对细胞侵袭能力的影响
Expression and its significance of GABA signal in gestational trophoblastic cell pathological tissues
摘要
Abstract
AIM: To explore the effects of GABAr agonist or antagonist on JAR cells invasion by identifying the expression of GABA,π subunit of GABARA, Bl subunit of GABARB (GABAB1R) in JAR cells and taking Transwell chamber with GABA or receptor agonist or antagonists. METHODS; The protein expression of GABA, GABRP, GABAB1R were measured by immunocytochemistry and western bolt in JAR cells. The Mrna GABRP, GABAB1R was measured by RT-PCR. The effects of GABA and its receptors agonists and antagonists on JAR cells invasion were assay by Transwell chamber. RESULTS: GABA, GABRP, GABAB1R were expressed in JAR cells. GABAA receptor agonist muscimol significantly promoted the invasion of JAR cells, while GABABR agonist baclofen significantly inhibited JAR cell migration. CONCLUSION: GABA signal may be associated with the pathogenesis of trophoblast-associated diseases of pregnancy.关键词
JAR细胞/γ-氨基丁酸/侵袭Key words
Trophoblast diseases/ γ-amino butyric acid/ Invasion分类
医药卫生引用本文复制引用
罗文萍,刘真真,彭洪英,谭冬梅,赵海,谭毅..γ-氨基丁酸信号在JAR细胞中的表达及对细胞侵袭能力的影响[J].中国临床药理学与治疗学,2012,17(3):274-279,6.基金项目
国家自然科学基金面上项目(30270510 （）
31171436) （）
重庆市教委项目(KJ110316) （KJ110316）
