中国临床药理学与治疗学2012，Vol.17Issue(5)：502-507,6.
芝麻素对自发性高血压大鼠肾病的保护作用
Renal protective effect of sesamin in spontaneously hypertensive rats
摘要
Abstract
AIM: To evaluate the protective effect of sesamin on kidney damage in spontaneously hypertensive rats (SHR). METHODS: Sesamin(160.80,40 mg/kg)was administrated to SHR intragastrically once a day for 16 weeks. The blood pressure (BP) before and after administration were measured. After the last BP measuring, rats were anesthetized. 5 mL of blood sample were collected from abdominal aorta for the detecting of blood urea nitrogen (BUN) and creatinine(Cr) concentration. The kidney was excised for HE and MASSON staining to observe the changes of pathology and collagen fibers. Glomerular ultrastructure was observed by transmission electron microscopy. RESULTS: After the administration of sesamin for 16 weeks, the BP.Cr and BUN were lowered significantly. Pathological changes such as glomerular distortion, atrophy, sclerosis and hya-linization were improved. There was no significant expansion in mesangial area, no thickening in basement membrane and no significant cell fusion of podocytes. Renal tubular cell injury and interstitial fibrosis was significantly reduced. CONCLUSION: Sesamin can improve the renal function of SHR kidneys and protect kidneys from damage.关键词
芝麻素/自发性高血压大鼠/肾脏/病理学变化/超微结构/间质纤维化Key words
Sesamin/ SHR/ Kidney/ Pathological changes/ Glomerular ultrastructure/ Interstitial fibrosis分类
医药卫生引用本文复制引用
杜少陵,杨解人,张俊秀,李文星..芝麻素对自发性高血压大鼠肾病的保护作用[J].中国临床药理学与治疗学,2012,17(5):502-507,6.基金项目
安徽省教育厅自然科学研究基金重点项目(No2006KJ099A) （No2006KJ099A）
芜湖市2008年度科技计划重点项目(N02008512) （N02008512）
