中国临床药理学与治疗学2012，Vol.17Issue(5)：508-512,5.
胺碘酮对SD大鼠甲状腺功能及形态影响的实验研究
Experimental study on the effects of amiodarone on thyroid function and morphology in SD rats
摘要
Abstract
AIM: To investigate the effects of amiodarone on thyroid hormone secretion, signaling protein expression and morphology. METHODS: SD rats were divided into low-dose group (50 mg · kg-1· d-1) and high-dose group (200 mg · kg-1 · d-1), feeding amiodarone for 14 weeks respectively. Free triiodothyronine (FT3), free thyroxine ( FT4), total protein (TP), glycerin three greases (TG) were measured from SD rats' blood. Analysis of the expression for Bcl-2 protein and the activity of Caspase-3 protein were observed from SD rats' thyroid gland, and pathology examination were performed. RESULTS:After amiodarone medication, SD rats' appearance were hair removal, sluggish, weight loss, serum total protein de- creased, FT3 decreased with amiodarone's dose increasing, FT4 in the low-dose group slightly increased, while in the high-dose group decreased. The positive expression of Bcl-2 in low-dose group and high-dose group, while negative expression of Caspase-3 in all of them (P > 0.05). CONCLUSION: Effects of amiodarone on SD rats' thyroid were manifested as thyroid hormone metabolism were inhibited with the dose increasing, and the expression of Bcl-2 protein were enhanced, while the apoptosis by Caspase-3 induced had not been initial.关键词
胺碘酮/甲状腺/Bcl-2蛋白/Caspase-3Key words
Amiodarone/ Thyroid/ Bcl-2/Caspase-3分类
医药卫生引用本文复制引用
江力勤,王志刚,季玉珍..胺碘酮对SD大鼠甲状腺功能及形态影响的实验研究[J].中国临床药理学与治疗学,2012,17(5):508-512,5.基金项目
浙江省科技厅公益性技术应用研究计划项目(2010C33008) （2010C33008）
浙江省嘉兴市科技计划项目(2010AY1036) （2010AY1036）
