中国临床药理学与治疗学2012，Vol.17Issue(5)：593-600,8.
细菌外排泵与抗生素耐药的相关性
Relation between bacterial efflux pump and antibiotic resistance
摘要
Abstract
Drug resistance in bacteria has attracted much attention in clinical antibacterial therapy for years. In addition to the well known mechanisms, such as inactivation of drugs and alteration of targets, drug extruding pumps also play a major role in resistance to antibacterials. Efflux pumps are widespread in bacteria and have broad variety of substrates. Their presence contributes both intrinsic and acquired bacterial resistance. Efflux-mediated drug-resistance has been recognized as the major mechanism of resistance to antibacterial agents in Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The impact of antibiotic efflux pumps on therapy must be taken fully into ac- count for the selection of antimicrobials. The design of specific, potent inhibitors appears to be an important goal for the improved control of infectious diseases in the near future. An alternative approach is to develop antibacterials that would bypass the action of efflux pumps. This paper will review recent progress on the role of bacterial efflux transporters in antibiotic resistance from the aspects of classification, structure, regulation and the inhibitors, which will provide references for the further investigation.关键词
外排泵/细菌/抗生素/耐药Key words
Efflux pump/ Bacteria/Antibiotics/ Drug resistance分类
医药卫生引用本文复制引用
孙渊,查伟斌,周芳,吴晓兰,张经纬,王广基..细菌外排泵与抗生素耐药的相关性[J].中国临床药理学与治疗学,2012,17(5):593-600,8.基金项目
“十一五”重大新药创制专项资助(2009ZX09304-001 （）
2009ZX09103) （）
国家自然科学基金资助(30973583) （30973583）
江苏省自然科学基金(BE2010723 （）
BK2010437) （）
