中国临床药理学杂志2012，Vol.28Issue(4)：249-252,4.
不同剂量右美托咪定对上腹部手术病人七氟烷呼气末有效浓度的影响
Effects of different doses of dexmedetomidine on end - tidal sevoflurance concentration in patients undergoing elective upper abdominal
马红 1冀翔宇 1王世端 1徐红梅 1宋力 1于文刚1
作者信息
- 1. 青岛大学医学院附属医院麻醉科,山东青岛 266003
- 折叠
摘要
Abstract
Objective To investigate the effects of different doses of dexmedetomidine on end - tidal sevoflurance concentration in patients undergoing elective upper abdominal. Methods Sixty ASA I or II patients undergoing elective upper abdominal surgery under general anesthesia were randomly allocated to one of three groups with 20 patients in each group :0. 4, 0. 8 μg · kg-1 of dexmedetomidine was administered by intravenous infusion in D1 group and D2group, respectively, and the same volume of physiological saline was infused in D0 group within 10 minutes before anesthesia induction. Intubation anesthesia was maintained with sevoflurance inhalation alone ( D0 group) or sevoflurance combined with dexmedetomidine by 0.4 or 0. 8 μg · kg-1 · h-1 infusion ( D1, D2 groups). Bispectral index (BIS) was maintained at 45 ~55 after tracheal intubation during maintenance of anesthesia. Results When BIS was maintained at 45 ~ 55, the end - tidal sevoflurance concentration was( 1. 7 ±0.4)% (D0 group), (1.4 ±0.2)% (D1 group) and(l. 0 ±0. 2)% ( D2 group) ,respectively. Heart rate and arterial pressure were more stable in group D2 than those of two other groups. Conclusion At the same depth of anesthesia, the end - tidal sevoflurance concentration was greatly reduced when combined with dexmedetomidine, and 0. 8 μG · kg -1 · h-1 dexmedetomidine combined with sevoflurance has little influence on patients' hemodynamic condition.关键词
右美托咪定/七氟烷/麻醉/吸入Key words
dexmedetomidine/ sevoflurance/ anesthesia/ inhalation分类
医药卫生引用本文复制引用
马红,冀翔宇,王世端,徐红梅,宋力,于文刚..不同剂量右美托咪定对上腹部手术病人七氟烷呼气末有效浓度的影响[J].中国临床药理学杂志,2012,28(4):249-252,4.
