中国临床药理学杂志2012，Vol.28Issue(4)：315-317,3.
全身麻醉剂对发育期大脑神经元凋亡的影响及其机制
Effect and mechanism of general anesthetics induced neurodegeneration in the developing brain
李民 1钱敏 1郭向阳 1马大青2
作者信息
- 1. 北京大学第三医院麻醉科,北京100191
- 2. 伦敦帝国学院麻醉科,英国 伦敦 SW10 9NH
- 折叠
摘要
Abstract
Recent reports from animal studies provide mounting evidence that exposure to anesthetics during the period of rapid synaptogenesis triggers widespread neuronal apoptosis in the developing brains and causes significant long - term neurocognitive impairment. Animal studies have confirmed that both the intrinsic and extrinsic pathways of the apoptotic cascade are involved in anesthetics induced apoptotic neurodegeneration. However, the exact cell signaling mechanisms for activation of the apoptotic cascade and cellular selectivity remains unclear. Recent preliminary data from human clinical studies is still scarce and has not demonstrated causal relationships between long - term developmental and behavioral disorders following surgery and anesthesia early in life. Further animal studies and well - designed clinical studies are needed to examine the mechanisms, clinical relevance and promising protecting strategies.关键词
全身麻醉剂/发育期大脑/神经元凋亡/术后认知功能障碍Key words
general anesthetics/developing brain/neuron apoptosis/postoperative cognitive dysfunction分类
天文与地球科学引用本文复制引用
李民,钱敏,郭向阳,马大青..全身麻醉剂对发育期大脑神经元凋亡的影响及其机制[J].中国临床药理学杂志,2012,28(4):315-317,3.
