注射用雷贝拉唑钠的人体药动学特征OACSTPCD
Pharmacokinetic characteristics of sodium rabeprazole in humans
目的 研究注射用雷贝拉唑铺的人体药动学特征.方法 30名健康志愿者分成低(10 mg)、中(20 mg)、高(40 mg)3个剂量组,单次给药后采取8h动态血样；中剂量组完成单次给药试验后即进入多次给药试验,采集动态血样.采用 LC-MS/MS法测定血浆中雷贝拉唑的浓度,并采用DAS软件计算药动学参数.结果 30名受试者分别单次给低、中、高3个剂量后雷贝拉唑的主要药动学参数ρmax分别为(699.89士198.89)、(1274.82土272.9…查看全部>>
AIM To study the pharmacokinetics of sodium rabeprazole injection in humans. METHODS Thirty healthy volunteers were randomly divided into 3 groups who received the sodium rabeprazole injection,and the doses were 10 mg, 20 mg and 30 mg, respectively. Each volunteer's blood samples were collected in 8 h after the injection.The 20 mg group's volunteers were given multiply dose subsequently when the first dose tests were finished and the blood samples were colle…查看全部>>
卢慧勤;戴婕;倪晓佳;张明;邱畅;温预关
广东省第二人民医院药学部,广州510317中山大学孙逸仙纪念医院药学部,广州510120广州市脑科医院药学部,广州510370广州市脑科医院药学部,广州510370广州市脑科医院药学部,广州510370广州市脑科医院药学部,广州510370
雷贝拉唑LC-MS/MS药动学特征
rabeprazoleLC-MS/MS pharmacokinetics
《中国临床药学杂志》 2012 (3)
148-153,6
广东省自然科学研究基金立项资助(编号8151037001000001),广东省科技计划社会发展领域立项(编号00498500130062027)
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