中国临床药学杂志2012，Vol.21Issue(3)：148-153,6.
注射用雷贝拉唑钠的人体药动学特征
Pharmacokinetic characteristics of sodium rabeprazole in humans
摘要
Abstract
AIM To study the pharmacokinetics of sodium rabeprazole injection in humans. METHODS Thirty healthy volunteers were randomly divided into 3 groups who received the sodium rabeprazole injection,and the doses were 10 mg, 20 mg and 30 mg, respectively. Each volunteer's blood samples were collected in 8 h after the injection.The 20 mg group's volunteers were given multiply dose subsequently when the first dose tests were finished and the blood samples were collected. LC-MS/MS was used to determine plasma concentrations of rabeprazole and pharmacokinetic parameters were calculated by DAS software. RESULTS The main pharmacokinetic parameters of rabeprazole in the 10 mg, 20 mg and 40 mg groups were as follows: ρmax were (699.89± 198.89),(1 274.82±272.99) and (2 572.00±640.57) μg· L-1;tmax were (0.53 ±0.09), (0.43 ±0.09) and (0.52 ±0.09) h;t1/2 were (1.34±0.47), (0.97±0.29) and (1.43 ±0.39) h; AUC0→8 were (864.23 ±369.13),(1477.88 ±311.65) and (3 444.86 ± 1 175.38) μg·h·L-1; AUC0→∞ were (877.16±379.48), (1 484.05±313.24) and (3 501.05± 1 236.70) μg·h·L-1,respectively. The main pharmacokinetic parameters of 20 mg group were as follows: pmax 88 was (1 299.50 ± 290.20) μg·L-1; tmax was (0.53±0. 10) h; t1/2 was (0. 89 ± 0. 29) h; AUC0→8 88 was (1 447. 08 ± 421. 03) μg·h·L-1; AUC0→∞ 88 was (1 454.19±420.65) μg·h·L-1; DF was (22.58 ± 5.50)%. CONCLUSION Sodium rabeprazole injection showes well linear pharmacokinetic characteristics in human body when the doses range from 10 mg to 40 mg.关键词
雷贝拉唑/LC-MS/MS/药动学特征Key words
rabeprazole/LC-MS/MS/ pharmacokinetics引用本文复制引用
卢慧勤,戴婕,倪晓佳,张明,邱畅,温预关..注射用雷贝拉唑钠的人体药动学特征[J].中国临床药学杂志,2012,21(3):148-153,6.基金项目
广东省自然科学研究基金立项资助(编号8151037001000001),广东省科技计划社会发展领域立项(编号00498500130062027) （编号8151037001000001）
