中国临床药学杂志2012，Vol.21Issue(3)：173-175,3.
地塞米松磷酸钠注射剂与甲钴胺注射剂在氯化钠注射剂中的稳定性考察
Investigation of the stability of the dexamethasone sodium phosphate injection and mecobalamin injection in sodium chloride injection
黄滔敏 1陈念祖 1王东蕾 1赖永华 1马勤 1闫晶超1
作者信息
- 1. 复旦大学附属眼耳鼻喉科医院药剂科,上海200031
- 折叠
摘要
Abstract
AIM To investigate the stability of dexamethasone sodium phosphate injection and mecobalamin injection in sodium chloride injection. METHODS Dexamethasone sodium phosphate and mecobalamin were determined by RP-HPLC method at 4℃ and normal temperature under natural illumination and nonillumination within 12 h. The appearance of the solution was observed and its pH value was determined. RESULTS No significant change was found in the terms of the appearance and the contents of the mixed solution, the changes of pH value were not more than 1.0 under nonillumination within 12 h. No significant change was found in the terms of the content of dexamethasone sodium phosphate under illumination within 12 h. However, more than 50% mecobalamin was degraded under natural illumination within 5 min. CONCLUSION The dexamethasone sodium phosphate injection and mecobalamin injection should not be simultaneously put in the sodium chloride injection for intravenous infusion.关键词
地塞米松磷酸钠/甲钴胺/氯化钠/配伍稳定性/高效液相色谱Key words
dexamethasone sodium phosphate/ mecobalamin/ sodium chloride/ compatible stability/HPLC引用本文复制引用
黄滔敏,陈念祖,王东蕾,赖永华,马勤,闫晶超..地塞米松磷酸钠注射剂与甲钴胺注射剂在氯化钠注射剂中的稳定性考察[J].中国临床药学杂志,2012,21(3):173-175,3.
